Endocrine Disease Gene Therapy
  • Windeatt, S., Southgate, T.D., Dewey, F., Bolognani, F., Perone, M.J., Larregina, A.T., Maleniak, T., White, A., Goya, R., Morris, I., Lowenstein, P.R. and Castro, M.G. Adenovirus-mediated HSV-1 thymidine kinase gene therapy suppressed oestrogen induced pituitary prolactinomas. Journal of Clinical Endocrinology & Metabolism 85: 1296-1305, 2000. Click here for the PDF (11.1MB)

  • Southgate, T.D., Windeatt, Smith-Arica, S., J., Gerdes, C.A., Perone, M.J., Morris, I., Davis, J.R.E., Klatzmann, D., Löwenstein, P.R. and Castro, M.G. Transcriptional targeting to anterior pituitary lactotrophic cells using recombinant adenovirus vectors in vitro and in vivo in normal and estrogen/sulpiride induced hyperplasic anterior pituitaries. Endocrinology, 141: 3493-3505, 2000. Click here for the PDF (1.4MB)

  • Davis, J.R.E. , McVerry, J., Lincoln, G.A., Windeatt, S., Lowenstein, P.R., Castro, M.G., McNeilly, A.S. Cell-type specific adenoviral transgene expression in the intact ovine pituitary gland after stereotaxic delivery: an in vivo system for long-term multiple parameter evaluation of human pituitary gene therapy Endocrinology, 142: 795-801, 2001. Click here for the PDF (.8MB)

  • Southgate TD, Stone D, Williams JC, Lowenstein PR, Castro MG. Long-term transgene expression within the anterior pituitary gland in situ: impact on circulating hormone levels, cellular and antibody-mediated immune responses. Endocrinology. 142: 464-76, 2001. Click here for the PDF (2MB)

  • Smith-Arica, J., Williams, J.C., Stone, D., Smith, J., Lowenstein, P.R. and Castro, M.G. Switching on and off transgene expression within lactotrophic cells in the anterior pituitary gland in vivo. Endocrinology, 142: 2521-32, 2001. Click here for the PDF (1MB)

  • Williams, J.C., Stone, D., Smith-Arica, J.R., Morris, I.D., Lowenstein, P.R., and Castro, M.G. Regulated, adenovirus-mediated delivery of tyrosine dyroxylase suppresses growth of estrogen induced pituitary prolactinomas. Molecular Therapy, 4:593-602, 2001. Click here for the PDF (18MB)

  • Davis JR, McMahon RF, Lowenstein PR, Castro MG, Lincoln GA, McNeilly AS. Adenovirus-mediated gene transfer in the ovine pituitary gland is associated with hypophysitis. J Endocrinol. May;173:265-71, 2002. Click here for the PDF (.4MB)

  • Sarac, M.S., Windeatt, S., Castro, M.G. and Lindberg, I. Intrapituitary adenoviral administration of 7B2 can extend the life span and reverse endocrinological deficiencies in 7B2 null mice. Endocrinology 143: 2314-2323, 2002.

  • Turvey, S. E., V. Gonzalez-Nicolini, C. I. Kingsley, A. T. Larregina, P. J. Morris, M. G. Castro, P. R. Lowenstein and K. J. Wood (2000). "Fas ligand-transfected myoblasts and islet cell transplantation." Transplantation 69(9): 1972-6.

  • Guillot, C., Coathalen, H., Chetritt, J., David, A., Lowenstein, P.R., Gilbert, E., Tesson, L., Van Rooijen, N., Cuturi, M.C., Sollilou, J.P., Anegon, I. Lethal hepatitis after gene transfer of IL-4 in the liver is independent of immune responses and dependent on apoptosis of hepatocytes: a rodent model of IL-4 induced hepatitis. Journal of Immunology, 166: 5225-5235, 2001.

  • Castro, M. G., T. Southgate and P. R. Lowenstein (2001). "Molecular therapy in a model neuroendocrine disease: developing clinical gene therapy for pituitary tumours." Trends Endocrinol Metab 12(2): 58-64. Click here for the PDF (.2MB)

  • Castro, M., S. Goverdhana, J. Hu, N. Jovel, X. Yuan and P. Lowenstein (2003). "Gene therapy for pituitary tumors: from preclinical models to clinical implementation." Front Neuroendocrinol 24(1): 62-77. Click here for the PDF (.4MB)

  • Castro, M. G., R. Cowen, J. Smith-Arica, J. Williams, S. Ali, S. Windeatt, V. Gonzalez-Nicolini, T. Maleniak and P. R. Lowenstein (2000). "Gene therapy strategies for intracranial tumours: glioma and pituitary adenomas." Histol Histopathol 15(4): 1233-52. Click here for the PDF(5.2MB)

  • Stirland JA, Seymour ZC, Windeatt S, Norris AJ, Stanley P, Castro MG, Loudon AS, White MR, Davis JR."Real-time imaging of gene promoter activity using an adenoviral reporter construct demonstrates transcriptional dynamics in normal anterior pituitary cells."J Endocrinol. 2003 Jul;178(1):61-9. Click here for the PDF (1.27 MB)

  • Pisera D, Candolfi M, Navarra S, Ferraris J, Zaldivar V, Jaita G, Castro MG, Seilicovich A."Estrogens sensitize anterior pituitary gland to apoptosis." Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E767-71. Epub 2004 Jun 1. Click here for the PDF (403 KB)

  • Candolfi M, Jaita G, Zaldivar V, Zarate S, Ferrari L, Pisera D, Castro MG, Seilicovich A."Progesterone antagonizes the permissive action of estradiol on tumor necrosis factor-alpha-induced apoptosis of anterior pituitary cells."Endocrinology. 2005 Feb;146(2):736-43. Epub 2004 Nov 4. Click here for the PDF (475 KB)

  • Jaita G, Candolfi M, Zaldivar V, Zarate S, Ferrari L, Pisera D, Castro MG, Seilicovich A."Estrogens up-regulate the Fas/FasL apoptotic pathway in lactotropes." Endocrinology. 2005 Nov;146(11):4737-44. Epub 2005 Aug 11. Click here for the PDF (475 KB)

  • Seilicovich A, Pisera D, Sciascia SA, Candolfi M, Puntel M, Xiong W, Jaita G, Castro MG."Gene therapy for pituitary tumors." Curr Gene Ther. 2005 Dec;5(6):559-72. Click here for the PDF (90.2KB)

  • Candolfi M, Jaita G, Pisera D, Ferrari L, Barcia C, Yu J, Liu G, Castro MG, Seilicovich A.(2006) Adenoviral vectors encoding tumor necrosis factor-alpha and FasL induce apoptosis of normal and tumoral anterior pituitary cells. Journal of Endocrinology 189(3):681-690. Click here for the PDF (2.87 MB)