Dolores Di Vizio, MD, PhD

Associate Professor of Surgery, Pathology and Laboratory Medicine, and Biomedical Sciences


Email:   dolores.divizio@cshs.org
Phone:  310-423-7709


Specialties

  • Molecular Pathology
  • Cell and Molecular Biology
  • Experimental Pathology


Education and Training

  • University of Naples, Italy; MD
  • University of Naples, Italy and Albert Einstein College of Medicine, New York, NY; PhD
  • Residency in Anatomic Pathology, University of Naples Federico II, Naples, Italy
  • Research fellow in Experimental Pathology and Translational Research, Harvard Medical School, Boston, MA


Research Interests

  • Mechanism of prostate cancer metastasis
  • Large oncosomes as biomarkers of tumor progression
  • Molecular and functional analysis of circulating large oncosome in tumors
  • Functional characterization of large oncosome miRNA cargo in human tumors
  • The functional role of Caveolin-1 in cancer associated fibroblasts


Awards and Activities

  • Editorial board, American Journal of Pathology
  • Editorial board, Carcinogenesis
  • Italian Ministry of Health, grant reviewer
  • CDMRP Prostate Cancer IDEA Panel


Selected Publications

  • Di Vizio, D., Kim, J., Hager, M.H., Morello, M., Yang, W., Lafargue, C., True, L., Rubin, M.A, Adam, R.M, Beroukhim, R., Demichelis, F., and Freeman, M.R. “Oncosome formation in prostate cancer: Association with a region of frequent chromosomal deletion in metastatic disease”. Cancer Res 69: 5601-9 (2009)
  • Di Vizio D., Morello M., Dudley A.C., Schow P.W., Adam R.M., Morley S., Mulholland D., Rotinen M., Hager M.H., Insabato L., Moses M.A., Demichelis F., Lisanti M.P., Wu H., Klagsbrun M., Bhowmick N.A., Rubin M.A., D'Souza-Schorey C., and Freeman M.R. "Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease." Am J Pathol, 181:1573-84. (2012).
  • Ayala G., Morello M., Danza G., Lisanti M.P., Freeman M.R., and Di Vizio D. "Loss of Caveolin-1 increases tumor cell migration, Is predictive of disease-free survival, and induces steroidogenesis in prostate-derived fibroblasts." Journal of Path 231(1):77-87 (2013)
  • Morello M., Minciacchi V.R., de Candia P., Gururajan M., Posadas E., Kim H., Chung L.W.K., Freeman M.R., Demichelis F., and Di Vizio D. Large oncosomes: MicroRNA profiling and identification in the circulation of patients with metastases. Cell Cycle 23;12(22). (2013)
  • Israelsen W.J., Dayton T.L., Fiske B.P., Hosios A., Bellinger G., Li J., Yu J., Sasaki M., Horner J.W., Burga L.N., Xie J., DePinho R.A., Jacks T., Wulf G.M., Di Vizio D., Mills G., Cantley L.C., Vander Heiden M.G. "PKM2 deletion reveals a differential requirement for pyruvate kinase in tumor cells." Cell 155(2):397-409 (2013)

Click here for a list of peer-reviewed publications by Dolores Di Vizio, MD, PhD.