Research and Outcomes

The Gastrointestinal Motility Program at Cedars-Sinai is conducting leading-edge research in several areas, including irritable bowel syndrome (IBS), small intestinal bacterial overgrowth (SIBO), and motility of the esophagus, stomach and small intestine.

The research interests of Mark Pimentel, MD, lie in the field of IBS as it relates to—bacteria in the small intestine. Recent findings suggest a very high prevalence of SIBO, a condition in which there is an inappropriate quantity of bacteria in the small intestine. This relationship has resulted in further research demonstrating that the elimination of these bacteria results in the most dramatic improvement in IBS symptoms. As such, the demand for breath testing has increased to rule out SIBO. Follow-up research on this topic has resulted in finding some of the motility problems of the small intestine possibly responsible for the overgrowth of bacteria. Furthermore, treatments to prevent the recurrence of the bacterial overgrowth and the IBS symptoms have been developed and have been found to be very effective.

The Pimentel Laboratory is currently conducting clinical studies related to SIBO. The lab is recruiting subjects with IBS and normal subjects. For more information on how to participate in these studies, please contact the research office at 310-423-3792.