Current Projects

The Cardiac Imaging Research Team (CIRT) is dedicated to fighting heart disease by developing powerful new diagnostic methods that can recognize at-risk individuals and evaluate atherosclerosis years or even decades before catastrophic events can occur.

CURRENT STUDIES:

 Cardiac Imaging Research Registry
 EISNER: Early Identification of Subclinical Atherosclerosis using NoninvasivE Imaging Program
 Automated Quantitative Plaque Characterization with Coronary CT Angiography
 ISCHEMIA: International Study of Comparative Health Effectiveness with Medical and Invasive Approaches - Nuclear Core Lab
 ASPIRE: A Phase 3 Study to Evaluate the Efficacy and Safety of Ad5FGF-4 Using SPECT MPI in Patients with Stable Angina Pectoris - Nuclear Core Lab
 

COroNary CT Angiography Evaluation For Clinical Outcomes: An InteRnational Multicenter Registry (CONFIRM) Registry

 Automated quantitative plaque characterization with coronary CT Angiography
 

Development and Optimization of Rubdium-82 Cardiac PET/CT for Myocardial Perfusion Imaging

 

High-Performance Automated System for Analysis of Cardiac SPECT

 


PROJECT DESCRIPTIONS:

Cardiac Imaging Research Registry

Principal Investigator: Daniel S. Berman, MD
IRB Approval Number: 1752
Contact: Nuria Mahmood (310) 423-3763
Status: Active - Enrolling

The Cardiac Imaging Research Registry is an organized system of information derived from historical, demographical, clinical, imaging, and outcomes data from patients undergoing cardiac imaging procedures including nuclear cardiology SPECT and PET, cardiac CT, and cardiac magnetic resonance imaging at Cedars-Sinai Medical Center for use in ongoing and future research that will help advance the field of cardiac imaging focused around the following general aims:

1) to investigate technical questions such as issues related to the acquisition parameters, image processing, and quantitative analysis,
2) to investigate diagnostic capabilities to detect disease and assess risk compared to other assessments,
3) to investigate prognostic value to predict adverse outcomes of cardiovascular disease (CVD) and all cause mortality, and
4) to investigate the usefulness of the testing to guide clinical decision making and monitor therapy with the goal of preventing adverse outcomes.

As of 2014, the registry contains approximately 60,000 cardiac SPECT, 20,000 coronary artery calcium (CAC) scans, 4,000 cardiac PET studies, 4,000 coronary CT angiography studies, and 1,500 cardiac MRI studies.

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EISNER: Early Identification of Subclinical Atherosclerosis using NoninvasivE Imaging Program

Principal Investigator: Daniel S. Berman, MD
IRB Approval Number: 3351 / 3974 / 3355
Contact: Romalisa Miranda-Peats (310) 423-6753
Status: Active - Data analysis only

Cardiac CT scanning has been shown to be useful in detecting subclinical coronary atherosclerosis, however the relative usefulness of cardiac CT findings, clinical, and biochemical assessments in predicting outcomes in coronary artery disease has not been fully explored. The Early Identification of Subclinical Atherosclerosis using NoninvasivE Imaging Research (EISNER) Study integrates the imaging (cardiac CT and nuclear cardiology), preventive cardiology, and basic cardiology aspects to improve the outcomes for coronary artery disease.

Study 1: CSMC Community (IRB# 3351)
The primary purpose of this prospective, randomized study is to determine if a particular combination of assessments (medical history and risk factor information, clinical and biochemical tests, and a cardiac CT scan) can predict future clinical outcomes (e.g. progression of atherosclerosis, heart surgery) in patients who have had no symptoms of coronary artery disease or other heart disease.

Study 2: Patients with Nuclear Cardiology Studies (IRB# 3974)
The primary purpose of this study is to determine if the information from a coronary calcium CT scan adds value to the information from a nuclear cardiology study in helping physicians make medical decisions.

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Automated Quantitative Plaque Characterization with Coronary CT Angiography

Principal Investigator: Damini Dey, PhD
IRB Approval Number: 19424
Contact: Damini Dey, PhD (310) 423-1517
Status: Active - Data analysis only

The investigators have developed a preliminary fully automatic volumetric analysis capable of accurate, rapid quantitation and characterization of atherosclerotic plaque lesions from standard coronary CT angiography and propose to refine, validate and evaluate the prognostic value of this approach. This goal will be accomplished through two specific aims: 1) validation of the developed methods by comparison to expert human observers and invasive “gold standard” modalities; and 2) assessment of the prognostic value in prediction of cardiac death.

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ISCHEMIA: International Study of Comparative Health Effectiveness with Medical and Invasive Approaches - Nuclear Core Lab

Principal Investigator: Daniel S. Berman, MD
IRB Approval Number: 25448
Contact: Rhona Littman (310) 423-4387
Status: Active - Data analysis only

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ASPIRE: A Phase 3 Study to Evaluate the Efficacy and Safety of Ad5FGF-4 Using SPECT MPI in Patients with Stable Angina Pectoris - Nuclear Core Lab

Principal Investigator: Daniel S. Berman, MD
IRB Approval Number: N/A
Contact: Rhona Littman (310) 423-4387
Status: Active - Data analysis only

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COroNary CT Angiography Evaluation For Clinical Outcomes: An InteRnational Multicenter Registry (CONFIRM) Registry
 

Principal Investigator: Daniel S. Berman, MD
IRB Approval Number: 26271
Contact: Lisa Miranda-Peats (310) 423-6753
Status: Active – Data Analysis only
 

The COroNary CT Angiography Evaluation For Clinical Outcomes: An InteRnational Multicenter Registry (CONFIRM) Registry was developed to examine the prognostic value of cardiac computed tomographic angiography (CCTA) findings for prediction of future adverse cardiac events related to coronary artery disease (CAD) in a large, international patient population. The purpose of this multicenter registry is to correlate coronary and non-coronary cardiac findings by CCTA with demographic and clinical data for refinement of risk stratification of individuals with suspected or known CAD.
 

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Automated quantitative plaque characterization with coronary CT Angiography
 

Principal Investigator: Damini Dey, PhD
IRB Approval Number: 19424
Contact: Lisa Miranda-Peats (310) 423-6753
Status: Active – Data Analysis only
 

In this project, investigators are developing automated methods to measure stenosis and characteristics of coronary plaque from noninvasive coronary CT angiography (CCTA). Additionally, they are developing an algorithm to integrate this information into a single score that may improve the prediction of future acute myocardial infarctions (AMI) and death; thus, allowing physicians to prescribe more personalized preventative care to their patients.
 

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Development and Optimization of Rubdium-82 Cardiac PET/CT for Myocardial Perfusion Imaging
 

Principal Investigator: Piotr Slomka, PhD
IRB Approval Number: 30679
Contact: Arpine Oganyan (310) 423-4225
Status: Active – Data Analysis only
 

The overall objective of this project is to develop and optimize technical aspects Rubdium-82 Cardiac PET/CT for myocardial perfusion imaging by conducting retrospective analysis on existing clinical data.  Currently, investigators are developing an automatic CT-PET registration which may improve the specificity in the diagnosis of coronary artery disease.
 

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High-Performance Automated System for Analysis of Cardiac SPECT
 

Principal Investigator: Piotr Slomka, PhD
IRB Approval Number: 19604
Contact: Arpine Oganyan (310) 423-4225
Status: Active – Data Analysis only
 

In this National of Institutes (NIH)-funded study, investigators are developing and validating an automated, highly-accurate and objective computer system which will outperform even experienced physicians in interpreting these images and consequently allow a greater number of lives saved by better selection of patients needing treatment and also resulting in time- and cost-savings.

 

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