Prediman K. (PK) Shah, MD, FACC, FACP, FCCP, Director, Division of Cardiology; Director, Atherosclerosis Research Center
  • Ellen Klapper, MD, Co-Director, Transfusion Medicine
  •  

    How the Procedure Works*

    • The patient's blood is withdrawn via a venous access and enters the plasma separator. As blood flows through the hollow fibers of the plasma separator, the plasma is separated and pumped into one of the two LDL adsorption columns. As the plasma passes through the column, the apolipoprotein B-containing lipoproteins - LDL, Lp(a) and VLDL - are selectively adsorbed by the dextran sulfate - cellulose beads within the column. There is minimal effect on other plasma components such as HDL and albumin.
    • The LDL-depleted plasma exits the column and is recombined with the blood cells exiting the separator, all of which is returned to the patient via a second venous access.
    • When the first column has completed adsorbing LDL, the computer-regulated machine automatically switches the plasma flow to the second column.
    • The plasma remaining in the first column is returned to the patient. The column is then regenerated, eluting the LDL, Lp(a) and VLDL to the waste lines. After elution the column is reprimed completely and ready for the next cycle of adsorption, allowing continuous LIPOSORBER treatment. A typical treatment takes two to four hours and must be repeated every two to three weeks.

    *This information is reprinted with permission from Kaneka, 2004.]]>" sling:resourceType="dxm/components/genericPageHero" title="LDL Apheresis" />