Lung transplantation has been provided at Cedars-Sinai Medical Center since 1988, when the program was the first of its kind in the western United States. Today, lung transplants are performed under the auspices of the multidisciplinary Women's Guild Lung Institute, part of the Comprehensive Transplant Center. As one of only a few medical centers in Southern California with Medicare certification for lung transplants, Cedars-Sinai offers a high level of experience and expertise in the surgical treatment of lung disease.
Indications for Lung Transplantation
- Single lung transplant: pulmonary fibrosis, sarcoidosis, emphysema, alpha-1-antitrypsin deficiency and eosinophilic granuloma
- Double lung transplant: bilateral pulmonary sepsis, cystic fibrosis, select cases of emphysema, primary pulmonary hypertension and Eisenmenger's syndrome with correctable cardiac defects
- Heart-lung transplant: Eisenmenger's syndrome with uncorrectable cardiac defects and pulmonary hypertension with severe left ventricular dysfunction
Candidates for Lung Transplantation
Candidates for lung transplants have end-stage lung disease with a poor prognosis and have failed to respond to conventional medical therapy. There are recommended age limitations: single lung transplantation is recommended for individuals who are under 65 years of age, double lung transplantation for those under 55 and heart-lung transplantation for those under 45.
Patients must be ambulatory and free of cancer, HIV or active infectious disease, and they must have normal function of other vital organs, such as the heart, liver and kidneys. Patients must not be active smokers or substance abusers. They also need a strong social and family support system to help in the early post-transplant recovery phase.
About Donated Lungs
Once an individual is deemed to be a good lung transplant candidate, he or she is listed with the United Network for Organ Sharing (UNOS). This organization is contracted by the federal government to procure and allocate donor organs fairly. For lung transplantation, patients who have spent the longest amount of time on the UNOS waiting list are the first to be matched to an available donor suitable for their size and blood type. Unlike other organs, no priority is given to patients for severity of disease.
Typically, patients must wait an average of 12 to 18 months for a donor lung. The long waiting times are attributed to the large number of patients listed and the limited number of donor organs suitable for transplant. Every lung transplant program in the country depends on the generosity of potential organ donors and their families.
How Lung Transplantation Is Performed
Transplantation surgery is performed with general anesthesia, using an incision on the side of the chest for single lung transplantation or across the sternum or breastbone for double and heart-lung transplantation.
The native diseased lung or lungs are removed from the recipient while the donor lung is being harvested. The donor lung (or allograft) is placed in the chest in the normal anatomic position. The new lung is then attached to the recipient by way of three anastomosis or connections, one for the bronchus, one for the pulmonary artery and one for the pulmonary veins. In the case of a double lung transplant, the procedure is repeated for the second lung in the other side of the chest. The incisions are then closed and two more chest tubes are placed around the new lung to help it re-expand with air.
After the surgery, the patient is transferred from the operating room into the intensive care unit, where close monitoring can be provided. Typically, patients are taken off the ventilator within 24 hours of the surgery's completion.
Treatment with immunosuppressive medication is begun to prevent rejection of the transplanted lung by the patient's immune system. Once stable and breathing on their own, patients are transferred to the surgical ward, where they can begin to get out of bed and walk. Most patients still need oxygen for a few days or weeks after the transplant, but eventually they can come off oxygen completely and walk without any shortness of breath or coughing.
Patients are closely monitored for any potential complications after surgery. In particular, physicians look for evidence of rejection, which now occurs infrequently, and any infection that can occur as a result of immunosuppression. Frequent blood tests and chest X-rays are required initially.
Patients are discharged from the Medical Center within 10 to 14 days of the surgery. The success of every transplant then depends on continued compliance with prescribed medication and close monitoring by the Women's Guild Lung Institute over the ensuing months and years.
As part of the Comprehensive Transplant Center, the Women's Guild Lung Institute provides a continuum of comprehensive treatments related to lung transplantation, individually tailored to each patient's specific needs. Available treatments include:
- Monitoring of patients awaiting a lung transplant
- Medical and surgical therapies, including Flolan therapy, lung volume reduction surgery (LVRS), lung transplantation and heart-lung transplantation
- Follow-up care including spirometry, bronchoscopy, transbronchial biopsies and management of immunosuppressive therapy
Cedars-Sinai's own Transplant Immunology Laboratory and HLA and Immunogenetics Laboratory provide pre-transplant analysis of genetic matching and antibodies that could cause rejection of a transplanted lung. The laboratories also offer a state-of-the-art monitoring system for detecting rejection and viral infections in an early phase, before a condition becomes life threatening. The rapid test results provided by the laboratories help improve patient and allograft survival, leading to better outcomes.
For More Information
Contact the Lung Transplantation Program at the Women's Guild Lung Institute