Inclusion and Exclusion Criteria

The following criteria outline who may be considered for lung transplantation -- and who is excluded from consideration.

Lung Transplantaton Inclusion Criteria

Patients may be considered for lung or heart/lung transplantation if they present with end-stage lung disease including the following conditions:

  • No response to conventional treatment
  • Limited life expectancy (less than two years)
  • Severely impaired lifestyle and exercise tolerance, NYHA Class III - IV symptoms
  • Oxygen dependence
  • Less than 75 years of age for single lung transplants
  • Less than 70 years of age for double lung transplants
  • Less than 60 years of age for heart/lung transplants

Lung Transplantation Exclusion Criteria

Patients may not be considered for lung or heart/lung transplantation if they exhibit any of the following:

  • Active or recent malignancy within two years of curative treatment without evidence of recurrence (within five years for breast cancer and melanoma)
  • Irreversible left-sided heat failure with an ejection fraction of less than 45% may only be a candidate for heart/lung transplantation.
  • High dose steroid therapy (more than 40 mg daily) that cannot be tapered or discontinued
  • Untreated or uncontrolled psychiatric disorders such as depression and psychosis
  • Extrapulmonary end-stage organ disease (multiple-organ transplant may be considered, when appropriate)
  • Known active infection or infection with highly resistant pathogens
  • History of noncompliance
  • Absence of strong social support system
  • Poor rehab potential

Relative Exclusion Criteria

The selection committee may use its discretion for the following relative exclusion criteria:

  • Ventilator dependency
  • Recent smoking history or substance abuse (within six months)
  • Severe cachexia and malnourishment (BMI less than 19)
  • Morbid obesity (BMI greater than 30)
  • Severe extrapulmonary or systemic disorders (i.e. active autoimmune disease, poorly controlled IDDM, coronary artery disease)
  • History of pleurodesis or pleural effusion
  • Presence of significant esophageal dysfunction