Principal Investigator: John S. Yu, MD
The Maxine Dunitz Neurosurgical Institute is also aggressively pursuing new gene-therapy strategies for intracranial lesions, modifying brain tumors to make them more vulnerable to attack either by the immune system or by chemotherapeutic drugs. Our scientists are focused specifically on genetic research as it relates to immunotherapy, investigating potential viruses to shuttle therapeutic genes to treat brain tumors.
There is an ongoing clinical trial that is using a oncolytic reovirus to attack recurrent malignant gliomas. In addition, the Institute is continually developing experimental therapies that they hope to translate into clinical trials. These trials will target brain tumors either by attacking the tumors directly with a virus or by developing gene transfer tools to shuttle in therapeutic genes via stem cells that target brain tumor cells.
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1. Samato K, Ehtesham M, Perng GC, Hashizume K, Wechsler SL, Nesburn AB, Black KL, Yu JS. A herpes simplex virus type 1 mutant deleted for gamma34.5 and LAT kills glioma cells in vitro and is inhibited for in vivo reactivation. Cancer Gene Therapy 8(4):269-277, 2001.
2. Samato K, Ehtesham M, Perng GC, Hashizume K, Wechsler SL, Nesburn AB, Black KL, Yu JS. A herpes simplex virus type 1 mutant with gamma34.5 and LAT deletions effectively oncolyses human U87 glioblastomas in nude mice. Neurosurgery 50(3):599-605, 2002.
3. Liu Y, Ehtesham M, Samoto K, Wheeler CJ, Thompson RC, Villareal LP, Black KL, Yu JS. In situ adenoviral interleukin 12 gene transfer confers potent and long-lasting cytotoxic immunity in glioma. Cancer Gene Ther 9:9-15, 2002.
4. Ehtesham M, Samoto K, Wheeler CJ, Thompson RC, Villareal LP, Black KL, Yu JS. Treatment of intracranial glioma with in situ interferon-gamma and tumor necrosis factor alpha gene transfer. Cancer Gene Therapy 9(11):925-934, 2002.
5. Ehtesham M, Kabos P, Kabosova A, Neuman T, Black KL, Yu JS. The use of interleukin 12 secreting neural stem cells for the treatment of intracranial glioma. Cancer Research 62:5657-5663, 2002. (Selected as cover illustration)
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