Pathology and Laboratory Medicine Research

The Department of Pathology and Laboratory Medicine at Cedars-Sinai is comprised of over 50 MDs and PhDs comprising an academic department recognized regionally, nationally and internationally. In the 2010-11 academic year, members of the department contributed over 100 papers in peer-reviewed journals, 13 book chapters and one books published by Department members,  who also presented more than 60 abstracts and 45 journal articles.   In aggregate, the faculty participated in more than 123 courses, lectureships and visiting professorships. Many of the Cedars-Sinai faculty members are on editorial boards of major high impact journals, and two faculty members function as journal editors, attesting to the professional esteem in which the faculty is held. 

The Department of Pathology at Cedars-Sinai has many areas of academic strength, focusing on translational and clinical research. These include genitourinary pathology under the guidance of Dr. Mahul Amin the chair and one of the most widely recognized authorities in genitourinary pathology globally, who brings to the program extensive expertise and academic success in oncologic pathology of the genitourinary tract. Other areas in which the department has strong research programs include GI and liver pathology, cytopathology, pulmonary and mediastinal pathology, evidence-based medicine, transfusion medicine, breast pathology, and renal pathology among others. There are strong clinical departments with which to collaborate, and all contemporary research modalities are available including molecular pathology techniques.

There is a strong commitment to incorporating pathology housestaff into the academic mission, with residents and fellows actively participating in research, ranging from case reports to complex translational studies. Research opportunities and mentoring are incorporated into the housestaff education, as evidenced by over 30 abstracts and presentations, 7 peer-reviewed housestaff publications and 11 abstracts/manuscripts submitted or in preparation during the 2010-11 academic year.  Also a high number of housestaff members had abstracts accepted for presentation at the 2011 USCAP meeting.  Our house staff contribution to scientific abstracts submitted has been in the top 10 programs in the world.

In addition to the many clinical and translational research programs with which the housestaff is involved, the Division of Experimental Pathology under the Directorship of Dr. Kenneth Bernstein brings internationally recognized expertise in the molecular mechanisms and biology of angiotensin converting enzyme and its receptors to the Cedars-Sinai Department of Pathology. Dr. Bernstein's laboratory has performed pioneering investigations in a wide range of experimental areas, including the control of ACE gene transcription, intracellular signaling initiated by angiotensin II, the role of ACE expression in the control of blood pressure, and the role of testis ACE in male reproduction. Recently, Dr. Bernstein made use of genetically modified mice to investigate the role of the renin-angiotensin system in the immune response to cancer. He has received several honors including an NIH MERIT award, the Novartis Prize from the American Heart Association, and the AHA's Basic Science Prize. With active NIH funding, the Experimental Pathology Division collaborates closely with the Cedars-Sinai Heart Institute, to provide the most state-of-the-art advances in this field of research. Dr. Bernstein is on the editorial board of three high impact journals, is a reviewer for more than 30 additional journals and also is a frequent grant reviewer, having sat on NIH study sections many times.