Other rare disorders

In addition, rarer disorders of the pituitary gland are also treated at the Cedars-Sinai Pituitary Center, including:

  • Empty sella syndrome, when pituitary tissue is destroyed with no evidence of a tumor or pituitary surgery or radiotherapy.
  • Familial multiple endocrine neoplasia type 1. Sometimes called Wermer syndrome, this condition affects the endocrine glands in men and women equally. It is caused by a defective gene that makes people more likely to develop tumors in the pituitary and other glands and the pancreas and parathyroid disease.
  • Kallmann's syndrome, which results in the people it affects failing to go through puberty unless they receive sex hormone replacement therapy. In addition, people with Kallmann's syndrome have no sense of smell.
  • Pituitary infarction, which is a loss of blood flow to the pituitary gland. It sometimes occurs because of an injury to the head. If the blood flow is cut off, the tissues of the gland can die causing hypopituitarism.
  • Rathke's cleft cysts, which are developmental abnormalities that happen before a child is born. The cysts develop in a part of the pituitary gland known as Rathke's pouch. Small Rathke's cleft cysts are not uncommon. Problems develop when the cysts grow and affect the pituitary gland or press on the optic chiasm.
  • Septo-optic dysplasia, which is a condition that affects both children and adults. It has three elements: 1) abnormal eye development, 2) abnormal development of the front part of the brain, and 3) abnormal pituitary gland development.
  • Sheehan's syndrome. During a normal pregnancy, the pituitary glad doubles in size. If a pregnant woman experiences a sudden drop in her blood pressure, a pituitary infarction can happen. This can lead to pan-hypopituitarism.
  • Wolfram syndrome. This is a group of conditions occurring at the same time: diabetes insipidus, diabetes mellitus, optic atrophy and deafness. It tends to run in families.