The Uro-Oncology Research Program is intimately integrated with the Louis Warschaw Prostate Cancer Research Center, with strong emphasis on basic science and translational research in prostate, kidney, and bladder cancers. The program is led by Leland W.K. Chung, PhD with close programmatic research collaborations among faculty and trainees. The program seeks extramural funding and research collaboration to advance knowledge and clinical translation. Currently, the program is funded by a NCI Program Project on "Prostate Cancer Bone Metastasis: Biology and Targeting", R01, and Department of Defense grants (see Recent Program Publications and cited acknowledgements for details).
|The research program, led by Leland Chung, PhD (center) is comprised of (l-r): Dolores DiVizio, MD, PhD, Edwin Posadas, MD, Neil Bhowmick, PhD, Daniel Luthringer, MD, Beatrice Knudsen, MD, PhD, and Hyung Kim, MD.|
Research focuses include:
- The biology, targeting and imaging of tumor-microenvironment interaction (Leland W.K.Chung, PhD)
- The pathogenesis and biomarkers associated with personalized oncology (Haiyen E. Zhau, PhD)
- The role of the tumor microenvironment on cancer initiation, progression and metastasis to determine patient risk of cancer progression and therapeutic intervention (Neil Bhowmick, PhD)
- The molecular basis of cancer growth and survival signaling (Wen-Chin Huang, PhD)
- Signal transduction and gene expression mechanism relevant to cancer progression and metastasis (Bekir Cinar, PhD)
- Targeting oxidative stress response mechanisms by radiation and cytotoxic antibodies (Sajni Josson, PhD)
- Immune-modulatory mechanisms of cancer growth and targeting (Murali Gururajan, PhD)
Collectively, strong inter- and intra-programmatic collaborations with the objectives of understanding the "cross-talk" between the tumor and its microenvironment, the development of new imaging, targeting, and biomarkers, and the acceleration of clinical translation of basic science discoveries from bench to bedside to improve the clinical outcome of patients with prostate, kidney, and bladder cancers.
The program faculty is also committed to the vital educational objectives of training graduate students, research scholars, clinical fellows, and exchange students.
Clinical Resources at Cedars-Sinai
For information on diagnostic testing and screening, prostate cancer treatments or to find a physician, please visit the following Cedars-Sinai clinical programs: