Pancreas Regeneration

Donald C. Dafoe, MD

Research is focused on the in vitro differentiation and propagation of insulin-producing cells derived from human embryonic stem cells (HESC). The laboratory is exploring the influence of endothelial-derived growth factors in these cells to promote full differentiation and maturation. The long-term goal is to use these cells as therapy in Type 1 diabetes mellitus.


Selected Publications

  • Ma, IWY, Valantine, HA, Shibata, A, Waskerwitz, J, Dafoe, DC, Alfrey, EJ, Tan, JC, Millan, M, Busque, S, Scandling, JD. Validation of a screening protocol for identifying low-risk candidates with type 1 diabetes mellitus for kidney with and without pancreas transplantation. Clin Transplant 2006: 20: 139-146.
  • Arafat HA, Katakam AK, Chipitsyna G, Gong Q, Vancha AR, Gabbeta J, Dafoe DC. Osteopontin Protects the Islets and {beta}-Cells from Interleukin-1 {beta}-Mediated Cytotoxicity through Negative Feedback Regulation of Nitric Oxide. Endocrinology. 2007 Feb;148(2):575-84.
  • Talavera D, Dafoe DC, Ng T, Wachsmann-Hogiu S, Castillo-Henkel C, Farkas DL. Enhancement of embryonic stem cell differentiation promoted by Avian Chorioallantoic membranes. Tissue Eng Part A. 2009 Oct; 15(10):3193- 3200.