|Philip Fleshner, MD||Colorectal Surgery|
|Nicholas Nissen, MD||Hepatobiliary Surgery, Liver Transplantation|
|Gordon Wu, PhD||Transplant Immunobiology|
|John Yu, MD||Neurosurgery|
Philip Fleshner, MD, FACS, Division of Colorectal Surgery
Clinical Interests: Inflammatory bowel disease, colon cancer, anorectal disorders
Research Interest: Predicting surgical outcomes in patients with ulcerative colitis and Crohn's disease
Brief Description of Research: Clinical research. You will be involved in clinical outcomes studies focusing on patients with inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease
Contact Information: Email, 310-289-9224
Nicholas Nissen, MD, FACS, Division of Liver Diseases & Transplantation
Clinical Interests: Liver surgery, Pancreas surgery, transplantation surgery
Research Interest: Outcomes research from pancreatic diseases, carcinoid, and neuroendocrine tumors
Brief Description of Research: Clinical research. You will be involved in studies on the morbidity and outcome of pancreatic resections. Also, you may choose to study the outcome of carcinoid and neuroendocrine tumor patients after treatment via a multidisciplinary approach.
Contact Information: Email, 310-423-2641
Gordon Wu, PhD, Transplant Immunobiology
Clinical Interests: Transplantation immunobiology, Immunological monitoring of pre- and post- transplant patients.
Research Interest: (1) Allograft fibrogenesis. (2) B cell production of alloreactive antibodies and T cell regulation. (3) Liver cirrhosis.
Brief Description of Research: The overall goal of this basic research project is to define the B cells that participate in memory responses to allogenic sensitization. This project involves use of a variety of investigation means, including transgenic mouse model of HLA sensitization (skin grafting), immunological characterization of alloreactive antibodies (Flow-cytometry, CDC assay, flow-PRA assay), and phenotypic definition of the B cells and T cells (qPCR, phenotyping with antibody markers). The summer student will be assigned to a sub-project and complete the project with assistance from other lab members.
Contact Information: Email
John Yu, MD, Department of Neurosurgery, Comprehensive Brain Tumor Program
Clinical Interests: Brain tumors, Immunotherapy
Research Interest: Brain tumor immunotherapy, clinical trials, development of bone marrow derived neural stem cells for neurologic disorders and targeting cancer stem cells. There is a particular need in our ongoing nanotechnology projects.
Brief Description of Research: Recently, we have developed antioxidant polymers which can be used as antioxidant polymeric therapeutics and as starting material for the preparation of antioxidant nanospheres. The antioxidant drug and/or delivery systems are oxidative stimuli-responsive and thus the therapeutics in the delivery systems will be released specifically in the site where the oxidative stress is present. This unique dual-functional therapeutic modality, provides a potential to combat the eactive oxygen species (ROS) and its producer in a stringently controlled manner, thus increases therapeutic index and reduce the adverse effect of the drug on normal cells and tissues. There have been many lines of evidence suggesting that the generation of ROS in the central nervous system (CNS) is a major risk factor for neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS).
Contact Information: Email, 310-423-8614