Christine Walsh, MD, MS

Physician, Gyn/Oncology
Email:christine.walsh@cshs.org
Phone:(310) 423-3599
Fax:(310) 423-0155

Institute Affiliation

Samuel Oschin Comprehensive Cancer Institute
Women's Cancer Research Institute

Academic Appointments

Assistant Professor, OBGYN

Awards and Activities

American Society of Clinical Oncology, Career Development Award2008
Pacific Ovarian Cancer Research Consortium, Career Development Award2007
Berlex Foundation, Berlex Scholar Award in Basic Science Research2007
Reviewer: Clinical Cancer ResearchCurrent
Reviewer: Cancer Epidemiology Biomarkers and PreventionCurrent
Reviewer: Gynecologic OncologyCurrent
Society of Gynecologic Oncologists2002
American Society of Clinical Oncology2004
American Association for Cancer Research2004

Research Focus

Genomic and molecular pathogenesis of ovarian cancer to identify novel biomarkers for disease prediction, prognosis, and targets for new treatment strategies. We are currenly focusing our studies on genes in DNA repair pathways and cell signalling proteins.

Research Contributions

Discovered a high degree of genetic instability among ovarian cancer genomes, with different patterns occurring in BRCA-associated and sporadic tumors. Identified cyclin E and ERCC5 as candidate genes important to ovarian cancer biology.

Current investigations include:

Genetic changes that modulate ovarian cancer response to chemotherapy. In vivo models of ovarian cancer. Biomarker predictor of ovarian cancer response to chemotherapy. Prognostic factors in gynecologic malignancies.

Selected Publications

  1. Walsh CS, Ogawa S, Karahashi H, Scoles DR, Pavelka JC, Tran H, Miller CW, Kawamata N, Ginther C, Dering J, Sanada M, Nannya Y, Slamon DJ, Koeffler HP, Karlan BY: ERCC5 is a novel biomarker of ovarian cancer prognosis. J. Clin. Oncol., 26(18): 2952-8, 2008
  2. Fejzo MS, Dering J, Ginther C, Anderson L, Ramos L, Walsh C, Karlan B, Slamon DJ: Comprehensive analysis of 20q13 genes in ovarian cancer identifies ADRM1 as amplification target. Genes Chromosomes Cancer, , 2008
  3. Song JH, Schnittke N, Zaat A, Walsh CS, Miller CW: FBXW7 mutation in adult T-cell and B-cell acute lymphocytic leukemias. Leuk. Res., , 2008
  4. Walsh CS, Karlan BY: Contemporary progress in ovarian cancer screening. Current oncology reports, 9(6): 485-93, 2007
  5. Walsh CS, Miller CW, Karlan BY, Koeffler HP: Association between a functional single nucleotide polymorphism in the MDM2 gene and sporadic endometrial cancer risk. Gynecol. Oncol., 104(3): 660-4, 2006
  6. Walsh C, Holschneider C, Hoang Y, Tieu K, Karlan B, Cass I: Coexisting ovarian malignancy in young women with endometrial cancer. Obstetrics and gynecology, 106(4): 693-9, 2005
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