Eduardo Marban, MD, PhD
Director, Heart Institute
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Institute Affiliation
Academic Appointments
| Professor, Medicine |
| Professor, Physiology |
Awards and Activities
| The Mark S. Siegel Family Professor | 2009 |
| Award for Outstanding Contribution to Cardiovascular Research, Gill Heart Institute | 2006 |
| Distinguished Scientist Award, American Heart Association | 2004 |
| Research Achievement Award, International Society for Heart Research | 2001 |
| Basic Research Prize, American Heart Association | 2000 |
| Louis and Artur Lucian Award for Research in Circulatory Diseases | 1998 |
| Research Career Development Award, N.I.H. | 1986 |
| Editor-in-Chief: Circulation Research | Current |
Research Focus
Developing the therapeutic postential of resident adult cardiac stem cells (CSCs) to promote a fast track to therapeutics. Developing appropriate harvesting and amplification methods of stem cells. Clinical research focus is on autologous CSC's in patients with cardiac dysfunction, including cell-based therapy. This research not only supports clinical studies but also translational work to image stem cell engratment, proliferation and differentiation in the heart.
Research Contributions
Elucidated fundamental mechanisms of cardiac dysfunction in stunned myocardium and other conditions related to ischemia and heart failure; founded the field of biological therapy for cardaic arrhythmias, notably gene-engineered biopacemakers; developed preclinical methods for isolation of cardsaic stem cells, leading to their clinical application in patients
Current investigations include:
stem cells for cardiac regeneration; cardiac electrophysiology
Selected Publications
- Barth AS, Kizana E, Smith RR, Terrovitis J, Dong P, Leppo MK, Zhang Y, Miake J, Olson EN, Schneider JW, Abraham MR, Marbán E: Lentiviral vectors bearing the cardiac promoter of the Na+-Ca2+ exchanger report cardiogenic differentiation in stem cells. Mol. Ther., 16(5): 957-64, 2008
- Smith RR, Barile L, Messina E, Marbán E: Stem cells in the heart: what's the buzz all about? Part 2: arrhythmic risks and clinical studies. Heart rhythm : the official journal of the Heart Rhythm Society, 5(6): 880-7, 2008
- Smith RR, Barile L, Messina E, Marbán E: Stem cells in the heart: what's the buzz all about?--Part 1: preclinical considerations. Heart rhythm : the official journal of the Heart Rhythm Society, 5(5): 749-57, 2008
- Marbán E, Cho HC: Biological pacemakers as a therapy for cardiac arrhythmias. Curr. Opin. Cardiol., 23(1): 46-54, 2008
- Cingolani E, Ramirez Correa GA, Kizana E, Murata M, Cho HC, Marbán E: Gene therapy to inhibit the calcium channel beta subunit: physiological consequences and pathophysiological effects in models of cardiac hypertrophy. Circ. Res., 101(2): 166-75, 2007
- Smith RR, Barile L, Cho HC, Leppo MK, Hare JM, Messina E, Giacomello A, Abraham MR, Marbán E: Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation, 115(7): 896-908, 2007
