Run Yu, PhD
Medical Director, Neuroendocrine Tumor Center
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Academic Appointments
| Assistant Professor, Medicine |
Awards and Activities
| Genentech Clinical Fellows Travel Grant from Endocrine Society | 2005 |
| AACR-AstraZeneca Scholar-in-Training Award from the American Association for Cancer Research | 2001 |
| Knoll Thyroid Research Clinical Fellowship Award from the Endocrine Society | 1999 |
Research Focus
Regulation of pancreatic beta cell mass using mouse models and cell culture to understand the humoral and intrinsic beta cell factors that determine beta cell mass.
Research Contributions
Showed that deletion of a cell cycle-regulating gene causes diminished beta cell mass. Found the mechanism is more beta cell apoptosis and senescence.
Current investigations include:
Mechanism of the apoptosis and senescence in beta cells. Role of DNA damage by deletion of a cell cycle-regulating gene.
Selected Publications
- Wang Z, Moro E, Kovacs K, Yu R, Melmed S: Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes. Proc. Natl. Acad. Sci. U.S.A., 100(6): 3428-32, 2003
- Yu R, Cruz-Soto M, Li Calzi S, Hui H, Melmed S: Murine pituitary tumor-transforming gene functions as a securin protein in insulin-secreting cells. J. Endocrinol., 191(1): 45-53, 2006
