Selected Reviews

Curtin JF, Candolfi M, Xiong W, Lowenstein PR, Castro MG. Turning the gene tap off; implications of regulating gene expression for cancer therapeutics. Mol Cancer Ther. 2008 Mar;7(3):439-48. Click here for the PDF
Lowenstein PR, Mandel RJ, Xiong WD, Kroeger K, Castro MG. Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions. Curr Gene Ther. 2007 Oct;7(5):347-60. Click here for the PDF
Lowenstein PR, Kroeger K, Castro MG. Immunology of neurological gene therapy: how T cells modulate viral vector-mediated therapeutic transgene expression through immunological synapses. Neurotherapeutics. 2007 Oct;4(4):715-24. Review. Click here for the PDF
Jacobs A.H., Castro M.G., and Lowenstein P.R., (2005) Human Gene Therapy and Imaging in Neurological Diseases. European Journal of Nuclear Medicine and Molecular Imaging 32 (Suppl.2):S358-383.
King, G.D., Curtin, J., Candolfi, M., Kroeger K., Lowenstein, P.R., Castro, M.G. (2005) Immune gene therapy and targeted toxins for glioma. Current Gene Therapy 5:535-557. Click here for the PDF (309 KB)
Curtin, JF, King GD, Candolfi, M, Greeno, RB, Kroeger, KM, Lowenstein, PR, Castro, MG (2005) Combining cytotoxic and immune-mediated gene therapy to treat brain tumors. Current Topics in Medicinal Chemistry 5: 1151-1170. Click here for the PDF (482 KB)
Seilicovich A, Pisera D, Sciascia S, Candolfi M, Puntel M, Xiong W, Jaita G, Castro MG, (2005) Gene Therapy for Pituitary Tumors. Current Gene Therapy 5(6):559-572.
Goverdhana, S., Puntel, M., Xiong, W., Zirger, JM, Barcia, C., Curtin, J.F., Soffer, E.B., Mondkar, S., King, G.D., Hu, J., Sciascia, S., Candolfi, M., Greengold, D.S., Lowenstein, P.R., and Castro, M.G. (2005) Regulatable gene expression systems for gene therapy applications: progress and future challenges. Molecular Therapy 12: 189-211. Click here for the PDF (669 KB)
Domingo E, Pariente N, Airaskinen A, Gonzalez-Lopez C, Sierra S, Herrera M, Grande-Perez A, Lowenstein PR, Manrubia SC, Lazaro E, Escarmis C (2005) Foot and mouth disease virus evolution: exploring pathways towards virus extinction. Current Topics Microbiol. Immunol. 288: 149-173.
Castro, M. G., J. R. Davis, W. Xiong and P. R. Lowenstein (1999). "Recent developments in gene therapy: applications for the treatment of pituitary tumours." Baillieres Best Pract Res Clin Endocrinol Metab 13(3): 431-49. Click here for the PDF(.2MB)
Stone, D., A. David, F. Bolognani, P. R. Lowenstein and M. G. Castro (2000). "Viral vectors for gene delivery and gene therapy within the endocrine system." J Endocrinol 164(2): 103-18. Click here for the PDF(.4MB)
Lowenstein, P. R. and M. G. Castro (2001). "Genetic engineering within the adult brain: implications for molecular approaches to behavioral neuroscience." Physiol Behav 73(5): 833-9. Click here for the PDF(.3MB)
Lowenstein, P. R. and M. G. Castro (2002). "Progress and challenges in viral vector-mediated gene transfer to the brain." Curr Opin Mol Ther 4(4): 359-71. Click here for the PDF (.6MB)
Stone, D., A. David, F. Bolognani, P. R. Lowenstein and M. G. Castro (2000). "Viral vectors for gene delivery and gene therapy within the endocrine system." J Endocrinol 164(2): 103-18. Click here for the PDF (.4MB)
Castro, M., S. Goverdhana, J. Hu, N. Jovel, X. Yuan and P. Lowenstein (2003). "Gene therapy for pituitary tumors: from preclinical models to clinical implementation." Front Neuroendocrinol 24(1): 62-77. Click here for the PDF (.4MB)
Lowenstein, P.R. Immunology of viral-vector-mediated gene transfer into the brain: an evolutionary and developmental perspective. Trends in Immunology: 23: 23-30, 2002. Click here for the PDF (.4MB)
Castro M.G., David, A., Hurtado-Lorenzo, A., Suwelack, D., Millan, E., Verakis, T. Xiong, W.D., Yuan X.P., Lowenstein, P.R. Gene therapy for Parkinson's disease: recent achievements and remaining challenges. Histology Histopathology 16: 1225-1238, 2001. Click here for the PDF (3.6MB)
Lowenstein P.R., Castro M.G. Genetic engineering within the adult brain: Implications for molecular approaches to behavioral neuroscience. Physiology and Behavior, 73: 833-9, 2001. Click here for the PDF (.3MB)
Castro, M.G., Davis, J.R., Xiong, W., and Lowenstein, P.R. Recent developments in gene therapy: applications for the treatment of pituitary tumors. Baillieres Best Practice Research in Clinical Endocrinology and Metabolism, 13: 431-449, 1999. Click here for the PDF (.2MB)
Castro, M.G., Southgate, T.D. and Lowenstein, P.R. Molecular therapies for pituitary tumours clinical implementation. Trends in Endocrinology and Metabolism, 12: 58-64, 2001. Click here for the PDF (.2MB)
Castro, M.G., Cowen, R, Smith-Arica, J., Williams, J., Ali, S., Windeatt, S., Gonzalez-Nicolini, V., Maleniak, T. and Lowenstein, P.R. Gene therapy strategies for intracranial tumors: gliomas and pituitary adenomas. Histology and Histopathology, 15: 1233-1252, 2000. Click here for the PDF (5.2MB)