Journal Clubs

11 a.m.-noon
PACT 811

Journal Clubs occur every other Thursday beginning Jan. 5, 2017.


May 17, 2017
10-11 a.m.
PACT 811

Early brain development in at-risk and normal children

Guest Speaker: John H. Gilmore, MD
Eure Professor and Vice Chair, Research
Director, University of North Carolina (UNC)
Center for Excellence in Community Mental Health
UNC Department of Psychiatry

June 1, 2017
11 a.m.-noon
PACT 811

Chemical Exchange Saturation Transfer (CEST): Towards Novel Applications

Presenter: Zhengwei (Jenny) Zhou, MS
PhD Candidate, UCLA
Visiting Grad Student, Biomedical Imaging Research Institute

Grand Rounds

May 4, 2017
Noon-1 p.m.
Davis 1004

ImmunoPET: Engineered antibodies for profiling tumors and immune responses

Speaker: Anna M. Wu, PhD, professor and vice chair, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Faculty, Crump Institute for Molecular Imaging

Abstract: Antibodies provide a versatile platform for noninvasive imaging of cells and tissues based on cell surface phenotype. We have developed engineered antibody fragments (minibody and diabody) with accelerated clearance properties, optimized for in vivo targeting and imaging.

When labeled with positron-emitting radionuclides (such as I-124, Zr-89, Cu-64, F-18), engineered fragments can be employed for high resolution, sensitive, quantitative imaging by PET (positron emission tomography) and provide highly specific molecular assessments of tumor biology and response to treatment.

For example, an I-124 prostate stem cell antigen (PSCA)-specific minibody demonstrates highly specific imaging in mouse models of prostate cancer and provides a PET imaging readout of response to enzalutamide treatment. ImmunoPET can be extended to the detection of cell surface markers on immune cell subsets such as CD4 or CD8 on T lymphocytes and CD20 on B lymphocytes, providing a means for assessing immune cell subsets.

Applications include imaging CD 8 and CD 4 T lymphocyte repopulation following stem cell transplantation, and monitoring CD8 cytotoxic T cell infiltration into tumors in cancer immunotherapy (e.g. treatment with anti-4-1BB or anti-PD-L1 antibodies, and adoptive transfer of OT-I T lymphocytes) in syngeneic mouse models. More recently, immunoPET has been extended to detection of CD4 T lymphocyte expansion in a model of inflammatory colitis.

ImmunoPET provides a broad approach for noninvasive, whole-body monitoring of key factors such as target expression in vivo, response to therapy, and immune responses. Furthermore, this approach is highly translatable, and stands to play an expanding role in the detection and management of cancer and other diseases.

March 10, 2017
10-11 a.m.
PEC 6-7

Probing Tumor Heterogeneity Using Advanced Diffusion Imaging

Speaker: Xiaohong Joe Zhou, PhD, director, Center for MR Research and professor, departments of Radiology and Bioengineering, University of Illinois

Abstract: Intra-tumor heterogeneity has been identified as one of the most important factors in making accurate diagnoses and tailoring therapy to individual patients. Tumor heterogeneity arises from a variety of origins such as genetics, epigenetics, physiology, and pathology, all of which lead to structural heterogeneity at a specific spatial scale.

Characterization of tumor structural heterogeneity can thus provide a unique avenue to probe the underlying biological processes and improve cancer patient care. Unfortunately, the current spatial resolution (e.g., hundreds of micrometer to a few millimeter) for human MRI is far from adequate to identify tissue structural heterogeneity at a microscopic level (e.g., ~5-50 micrometer).

Efforts to further improve the resolution face formidable technical challenges. An alternative strategy is to rely on the present spatial resolution, but focus on extracting sub-voxel information by linking a macroscopic voxellevel measurement to a microscopic intra-voxel physical process that reflects tissue structural heterogeneity.

Using a novel diffusion model based on continuous-time random walk (CTRW) and its associated fractional order calculus (FROC), our group has observed an increasing number of evidences suggesting a strong link between voxellevel macroscopic anomalous diffusion parameters and microscopic sub-voxel tissue heterogeneity.

This presentation will describe the CTRW and FROC diffusion models, illustrate the associated diffusion imaging techniques, and demonstrate a number of clinical applications. In these applications, anomalous diffusion parameters have been found useful to probe tumor heterogeneity at a sub-voxel level to improve diagnostic accuracy or predict cancer response to targeted therapy.

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See a list of previous BIRI events.