Adam Mamelak, MD

Director, Functional Neurosurgery Program, Neurosurgery

Co-Director, Pituitary Center

Email:adam.mamelak@cshs.org
Phone:310-423-7900
Fax:(310) 423-0810

Academic Appointments

Professor, Neurosurgery

Awards and Activities

ABTF AANS/CNS Award for Translational Research1999
AANS Young Clinician Investigator Award1997 - 1998
Magna Cum Laude, Harvard Medical School1990
Benjamin G. Brown Scholarship for Scientific Excel1990
Summa Cum Laude1985
Ad Hoc Reviewer, Cancer Therapy, UKCurrent
Ad Hoc Reviewer, EpilepsiaCurrent
American Epilepsy Society1992
American Association of Neurological Surgeons1992
Society of Neuro-Oncology1998
American College of Surgeons2001
Pituitary Society2007
International Soceity of Pituitary Surgeons2007

Research Focus

Pituitary tumor and endoscopic skull base surgiery technical development. Developing and testing new equipment and methods for minimally invasive surgery of pituitary and skull base tumors, and studying the pathogenesis of these tumors.
Neural basis of learing and memory- Studying the neurphysiological basis of memory processes in patients with implanted electrodes for identification of seizures.

Research Contributions

Performed first clinical trial of a synthetic scorpion venom used to treat malignant brain tumors. Identified neurons in the human brain that detect novelty or familiarity in single-trial learning.

Current investigations include:

Use of time resolved laser flourescence to detect brain tumors. Clinical trials of synthetic scorpion toxin for malignant brain tumors. Development of an exoscope system for human neurosurgery. Advancement of endoscopic skull base techniques. Establishment of a canine model for pituitary surgery to treat Cushing's Disease.

Selected Publications

  1. Mamelak AN, Rosenfeld S, Bucholz R, Raubitschek A, Nabors LB, Fiveash JB, Shen S, Khazaeli MB, Colcher D, Liu A, Osman M, Guthrie B, Schade-Bijur S, Hablitz DM, Alvarez VL, Gonda MA: Phase I single-dose study of intracavitary-administered iodine-131-TM-601 in adults with recurrent high-grade glioma. J. Clin. Oncol., 24(22): 3644-50, 2006
  2. Rutishauser U, Schuman EM, Mamelak AN: Activity of human hippocampal and amygdala neurons during retrieval of declarative memories. Proc. Natl. Acad. Sci. U.S.A., 105(1): 329-34, 2007
  3. Rutishauser U, Mamelak AN, Schuman EM: Single-trial learning of novel stimuli by individual neurons of the human hippocampus-amygdala complex. Neuron, 49(6): 805-13, 2006
  4. Mamelak AN, Lopez N, Akhtari M, Sutherling WW: Magnetoencephalography-directed surgery in patients with neocortical epilepsy. J. Neurosurg., 97(4): 865-73, 2002
  5. Mamelak AN, Dowd CF, Tyrrell JB, McDonald JF, Wilson CB: Venous angiography is needed to interpret inferior petrosal sinus and cavernous sinus sampling data for lateralizing adrenocorticotropin-secreting adenomas. J. Clin. Endocrinol. Metab., 81(2): 475-81, 1996
  6. Quattrochi JJ, Mamelak AN, Madison RD, Macklis JD, Hobson JA: Mapping neuronal inputs to REM sleep induction sites with carbachol-fluorescent microspheres. Science, 245(4921): 984-6, 1989
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