Ali Khoynezhad, MD, PhD

Director of Thoracic Aortic Surgery Program, Cardio-Thoracic Surgery

Email:akhoy@cshs.org
Phone:(310) 423-3851
Fax:(310) 423-0127

Academic Appointments

Professor, Surgery

Awards and Activities

AATS Leadership Awardee2013
Who's Who Among Executives, Professionals, and Entrepreneurs2012
Award for Excellence, American College of Cardiology2012
Best Doctors in America 2011 - 2013
German Travelling Fellowship Award2011
Section Editor: Operative Techniques in Thoracic and Cardiovascular SurgeryCurrent
Section Editor: PanVascular IICurrent
Editorial Advisory Board member: Open Heart Failure Journal2009 - 2013
Editor: The Cardiothoracic Surgery Network2006 - 2013
American College of Surgeons1999
Society of Thoracic Surgeons2004
International Society of Minimal Invasive Cardiac Surgery2008
Society for Heart Valve Disease2009
Beverly-Hills Iranian-American Medical Association2010
American Association for Thoracic Surgery2010
Academy of Persian Physicians2011
21st Century Cardiothoracic Surgical Society2013

Research Focus

Spinal cord ischemia resulting in paraplegia may be attenuated using novel anti-inflammatory medication such as NMDA-receptor blockers, adjuncts such as ischemic pre- and post-conditioning, and novel stem cell therapeutics. The effectiveness of these promising agents are tested validated in animal model, effective dose-response is established, prior to first-in-human experiments. Second project entails transcatheter aortic valve replacement in mechanical aortic valve prosthesis.

Research Contributions

Leader in outcome research of patients undegoing open and endovascular procedures for aortic dissection; developed classification for endovascular repair of acute type B dissection predicting false lumen-patency in mid- and long-term follow-up.

Current investigations include:

Modulating ischemic response of spinal cord. Developing in vitro model of acute type A dissection. Endovascular repair of aortic root and ascending aorta. Transcatheter valve replacement in patients with mechanical aortic valve. Microsurgical approach to intracardiac operation using transfemoral access. Minimal-invasive endoluminal cardotid-subclavian bypass. Transcatheter aortic valve replacement in mechanical aortic valve prosthesis.

Selected Publications

  1. Khoynezhad A, White RA: Pathogenesis and management of retrograde type a aortic dissection after thoracic endovascular aortic repair. Ann Vasc Surg, 27(8): 1201-6, 2013
  2. Swerdlow CD, Kass RM, Khoynezhad A, Tang S: Inside-out insulation failure of a defibrillator lead with abrasion-resistant coating. Heart rhythm : the official journal of the Heart Rhythm Society, 10(7): 1063-6, 2013
  3. Khoynezhad A, Azizzadeh A, Donayre CE, Matsumoto A, Velazquez O, White R, RESCUE investigators: Results of a multicenter, prospective trial of thoracic endovascular aortic repair for blunt thoracic aortic injury (RESCUE trial). J. Vasc. Surg., 57(4): 899-905.e1, 2013
  4. Pisimisis GT, Khoynezhad A, Bashir K, Kruse MJ, Donayre CE, White RA: Incidence and risk factors of renal dysfunction after thoracic endovascular aortic repair. J. Thorac. Cardiovasc. Surg., 140(6 Suppl): S161-7, 2010
  5. Brecht R, Friedrich M, Heinisch PP, Plonien K, Akra B, Hagl C, Khoynezhad A, Lutter G, Bombien R: Transcatheter valve replacement: new concepts for microsurgery inside the heart. Innovations (Phila), 8(1): 29-36

Lab Information