Christine Walsh, MD, MS

Director, Fellowship Program, Gynecologic Oncology

Email:christine.walsh@cshs.org
Fax:(310) 423-0155

Institute Affiliation

Cancer Institute

Academic Appointments

Assistant Professor, Obstetrics and Gynecology
Assistant Professor, OBGYN

Awards and Activities

APGO Faculty Teaching Award2011
Walter T. Danreuther AAOGF Travel Award2010
Career Development Award: Department of Defense Ovarian Cancer Research Program (DOD OCRP)2008
UCLA Clinical and Translational Science Institute (CTSI) Scholars Program2008
Career Development Award: American Society of Clinical Oncology2008
Cedars-Sinai Medical Staff Leadership Development Program2008
Pacific Ovarian Cancer Research Consortium2007
Faculty Golden Apple Teaching Award2007
Gynecologic Oncology Case ReportsCurrent
American College of Obstetricians and Gynecologists (ACOG)1998
Society of Gynecologic Oncologists (SGO)2002
American Society of Clinical Oncology (ASCO)2004
American Association for Cancer Research (AACR)2004
Western Association of Gynecologic Oncologists (WAGO)2008

Research Focus

Genomic and molecular pathogenesis of ovarian cancer to identify novel biomarkers for disease prediction, prognosis, and targets for new treatment strategies. We are currenly focusing our studies on genes in DNA repair pathways and cell signalling proteins.

Research Contributions

Discovered a high degree of genetic instability among ovarian cancer genomes, with different patterns occurring in BRCA-associated and sporadic tumors. Identified cyclin E and ERCC5 as candidate genes important to ovarian cancer biology.

Current investigations include:

Genetic changes that modulate ovarian cancer response to chemotherapy. In vivo models of ovarian cancer. Biomarker predictor of ovarian cancer response to chemotherapy. Prognostic factors in gynecologic malignancies.

Selected Publications

  1. Walsh CS, Ogawa S, Karahashi H, Scoles DR, Pavelka JC, Tran H, Miller CW, Kawamata N, Ginther C, Dering J, Sanada M, Nannya Y, Slamon DJ, Koeffler HP, Karlan BY: ERCC5 is a novel biomarker of ovarian cancer prognosis. J. Clin. Oncol., 26(18): 2952-8, 2008
  2. Fejzo MS, Dering J, Ginther C, Anderson L, Ramos L, Walsh C, Karlan B, Slamon DJ: Comprehensive analysis of 20q13 genes in ovarian cancer identifies ADRM1 as amplification target. Genes Chromosomes Cancer, , 2008
  3. Song JH, Schnittke N, Zaat A, Walsh CS, Miller CW: FBXW7 mutation in adult T-cell and B-cell acute lymphocytic leukemias. Leuk. Res., , 2008
  4. Walsh CS, Karlan BY: Contemporary progress in ovarian cancer screening. Current oncology reports, 9(6): 485-93, 2007
  5. Walsh CS, Miller CW, Karlan BY, Koeffler HP: Association between a functional single nucleotide polymorphism in the MDM2 gene and sporadic endometrial cancer risk. Gynecol. Oncol., 104(3): 660-4, 2006
  6. Walsh C, Holschneider C, Hoang Y, Tieu K, Karlan B, Cass I: Coexisting ovarian malignancy in young women with endometrial cancer. Obstetrics and gynecology, 106(4): 693-9, 2005

Lab Information

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