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Dianhua Jiang, MD, PhD
Research Scientist, Pulmonary & Critical Care Medicine
Research Scientist, Immunology Research
Awards and Activities
|American Thoracic Society||1999|
|American Physiological Society||2010|
|Chinese Association of Physiological Sciences||2011|
|Chinese American Lung Association||2012|
My research focuses on cellular and molecular mechanisms of lung inflammation and fibrosis, the role of lung stem cells in pulmonary fibrosis, and the role of host defense in lung inflammation and fibrosis.
Discovered Toll-like receptors as the signaling receptors for glycosaminoglycan hyaluronan during non-infectious lung injury; identified the role of hyaluronan synthase in promoting fibroblast invasion during fibrogenesis, and discovered the role of chemokine CXCL10 in regulation of fibroblast migration during lung fibrosis. Leader in hyaluronan biology.
Current investigations include:
The overall goal of the lab is to understand the molecular mechanisms of lung inflammation and fibrosis.
1. Innate immunity and matrix interactions regulate lung injury and repair. We are interested in the role of innate immune components (Toll-like receptors) in lung injury, repair, and fibrosis. We are using genetically modified mice targeting TLR receptors, TLR signaling molecules, hyaluronan synthase to investigate the mechanism of TLR components in pulmonary fibrosis.
2. Molecular mechanisms of lung fibrogenesis. We are interested in the sources of fibrotic fibroblasts, epithelial-mesenchymal communications, and transcriptional control of fibroblast activation.
3. Role of chemokines and chemokine receptors in lung injury and repair. We are interested in the immunoregulatory and molecular roles of CXCL10, CXCR3, CXCL12, and CCL2 in lung injury and repair. We are using transgenic and knockout mice to define the mechanisms of these chemokines and their receptors in pulmonary fibrosis, especially stem cell recruitment and maintenance, inflammatory cell recruitment and activation, and epithelial cell integrity.
4. Role of microRNA lung injury. We are interested in the role of microRNA in lung injury and repair. We are examining microRNA expression pattern during tissue injury, and are generating genetically modified mice targeting specific miRNAs.
5. Role of beta-arrestins in lung injury and fibrosis.
- Xie T, Liang J, Liu N, Wang Q, Li Y, Noble PW, Jiang D: MicroRNA-127 inhibits lung inflammation by targeting IgG Fc¿ receptor I. J. Immunol., 188(5): 2437-44, 2012
- Lovgren AK, Kovacs JJ, Xie T, Potts EN, Li Y, Foster WM, Liang J, Meltzer EB, Jiang D, Lefkowitz RJ, Noble PW: ß-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix. Sci Transl Med, 3(74): 74ra23, 2011
- Li Y, Jiang D, Liang J, Meltzer EB, Gray A, Miura R, Wogensen L, Yamaguchi Y, Noble PW: Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44. J. Exp. Med., 208(7): 1459-71, 2011
- Jiang D, Liang J, Campanella GS, Guo R, Yu S, Xie T, Liu N, Jung Y, Homer R, Meltzer EB, Li Y, Tager AM, Goetinck PF, Luster AD, Noble PW: Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4. J. Clin. Invest., 120(6): 2049-57, 2010
- Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, Prestwich GD, Mascarenhas MM, Garg HG, Quinn DA, Homer RJ, Goldstein DR, Bucala R, Lee PJ, Medzhitov R, Noble PW: Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat. Med., 11(11): 1173-9, 2005
- Teder P, Vandivier RW, Jiang D, Liang J, Cohn L, Puré E, Henson PM, Noble PW: Resolution of lung inflammation by CD44. Science, 296(5565): 155-8, 2002