Donald Dafoe, MD

Director, Surgical Education, Surgery

Director, Pancreas Transplantation Program, Comprehensive Transplant Center

Email:donald.dafoe@cshs.org
Phone:(310) 423-4848
Fax:(310) 423-3864

Institute Affiliation

Regenerative Medicine Institute

Academic Appointments

Professor, Surgery

Awards and Activities

Eris M. Field Chair in Diabetes Research2005
Alpha Omega Alpha Honorary Medical Society1975
Editorial Board Member: Journal of Surgical Research1994 - 2004
American College of Surgeons1985

Research Focus

Clinical investigation: Islet and pancreas transplantation in the treatment of diabetes mellitus.

Basic research: Growth and development of insulin-producing cells from embryonic stem cells.

Research Contributions

Clinical: Refined criteria and limits of extended criteria donor and dual renal allografts. Described developments in renal and pancreas transplantation over 30 years.

Basic science: Demonstrated the trophic effects of growth hormones on the development of transplanted fetal pancreas in diabetic rats.

Current investigations include:

Coaxing mouse and human embryonic stem cells to develop into mature islets in a diabetic SCID mouse model.

Selected Publications

  1. Talavera-Adame D, Dafoe DC, Ng TT, Wachsmann-Hogiu S, Castillo-Henkel C, Farkas DL: Enhancement of embryonic stem cell differentiation promoted by avian chorioallantoic membranes. Tissue Eng Part A, 15(10): 3193-200, 2009
  2. Talavera-Adame D, Ng TT, Gupta A, Kurtovic S, Wu GD, Dafoe DC: Characterization of microvascular endothelial cells isolated from the dermis of adult mouse tails. Microvasc. Res., 82(2): 97-104, 2011
  3. Talavera-Adame D, Wu G, He Y, Ng TT, Gupta A, Kurtovic S, Hwang JY, Farkas DL, Dafoe DC: Endothelial cells in co-culture enhance embryonic stem cell differentiation to pancreatic progenitors and insulin-producing cells through BMP signaling. Stem Cell Rev, 7(3): 532-43, 2011
  4. Desai DM, Adams GA, Wang X, Alfrey EJ, Sibley RK, Dafoe DC: The influence of combined trophic factors on the success of fetal pancreas grafts. Transplantation, 68(4): 491-6, 1999
  5. Arafat HA, Katakam AK, Chipitsyna G, Gong Q, Vancha AR, Gabbeta J, Dafoe DC: Osteopontin protects the islets and beta-cells from interleukin-1 beta-mediated cytotoxicity through negative feedback regulation of nitric oxide. Endocrinology, 148(2): 575-84, 2006
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