Eduardo Marban, MD, PhD

Director, Heart Institute

Email:eduardo.marban@csmc.edu
Phone:(310) 423-7557
Fax:(310) 423-7637

Institute Affiliation

Heart Institute

Academic Appointments

Professor, Medicine
Professor, Physiology

Awards and Activities

Award for Outstanding Contribution to Cardiovascular Research, Gill Heart Institute2006
Distinguished Scientist Award, American Heart Association2004
Research Achievement Award, International Society for Heart Research2001
Basic Research Prize, American Heart Association2000
Louis and Artur Lucian Award for Research in Circulatory Diseases1998
Research Career Development Award, N.I.H.1986
Editor-in-Chief: Circulation Research1999 - 2009

Research Focus

The current research areas are using biologically based therapies for cardiac regeneration and biological pacemakers. All lab members have a specific role in conducting their research that will enable the Marbán Lab to translate their work from the bench to bedside. The research using CDCs has demonstrated cells are better in their functional repair capacity and in their angiogenic ability to secrete favorable paracrine factors that other cells currently in clinical use do not. The lab is now studying various methods of delivering the cells and determining the immunogenicity of allogeneic stem cells in small and large animal models.

Research Contributions

Elucidated fundamental mechanisms of cardiac dysfunction in stunned myocardium and other conditions related to ischemia and heart failure; founded the field of biological therapy for cardaic arrhythmias, notably gene-engineered biopacemakers; developed preclinical methods for isolation of cardsaic stem cells, leading to their clinical application in patients

Current investigations include:

stem cells for cardiac regeneration, cardiac electrophysiology, biopacemakers, exosomes

Selected Publications

  1. Barth AS, Kizana E, Smith RR, Terrovitis J, Dong P, Leppo MK, Zhang Y, Miake J, Olson EN, Schneider JW, Abraham MR, Marbán E: Lentiviral vectors bearing the cardiac promoter of the Na+-Ca2+ exchanger report cardiogenic differentiation in stem cells. Mol. Ther., 16(5): 957-64, 2008
  2. Smith RR, Barile L, Messina E, Marbán E: Stem cells in the heart: what's the buzz all about? Part 2: arrhythmic risks and clinical studies. Heart rhythm : the official journal of the Heart Rhythm Society, 5(6): 880-7, 2008
  3. Smith RR, Barile L, Messina E, Marbán E: Stem cells in the heart: what's the buzz all about?--Part 1: preclinical considerations. Heart rhythm : the official journal of the Heart Rhythm Society, 5(5): 749-57, 2008
  4. Marbán E, Cho HC: Biological pacemakers as a therapy for cardiac arrhythmias. Curr. Opin. Cardiol., 23(1): 46-54, 2008
  5. Cingolani E, Ramirez Correa GA, Kizana E, Murata M, Cho HC, Marbán E: Gene therapy to inhibit the calcium channel beta subunit: physiological consequences and pathophysiological effects in models of cardiac hypertrophy. Circ. Res., 101(2): 166-75, 2007
  6. Smith RR, Barile L, Cho HC, Leppo MK, Hare JM, Messina E, Giacomello A, Abraham MR, Marbán E: Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation, 115(7): 896-908, 2007