H Phillip Koeffler, MD

Physician, Hematology/Oncology

Fax:(310) 423-0443

Institute Affiliation

Cancer Institute

Academic Appointments

Professor, Medicine

Awards and Activities

Mark Goodson Chair in Oncology Research1997

Research Focus

Molecular pathogenesis of cancers with a particular focus on brain, breast, lung and pancreas cancers, as well as leukemias and lymphomas. Translational research testing a variety of novel compounds for their anti-cancer activity and mechanism of action.

Research Contributions

Identified novel molecular defects in cancer including first report of p53 mutations in human cancer; first report of a new cyclin A1; first report of a new transferrin receptor known as transferrin receptor 2; Characterized novel phenotype of several types of mice with specific genetic deletions including those with Vitamin D receptor deletion, C/EBP-epsilon and -beta knock-out.

Current investigations include:

Studies of circadian rhythm in cancer, adaptor proteins that work in a negative fashion against cytokine receptors and the neighboring downstream proteins. Molecular defects in a variety of cancers using high throughput analysis including genome sequencing and single nucleotide polymorphic arrays, as well as studying a variety novel drug that have anti-cancer activities.

Selected Publications

  1. Kawamata N, Ogawa S, Zimmermann M, Kato M, Sanada M, Hemminki K, Yamatomo G, Nannya Y, Koehler R, Flohr T, Miller CW, Harbott J, Ludwig WD, Stanulla M, Schrappe M, Bartram CR, Koeffler HP: Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray. Blood, 111(2): 776-84, 2007
  2. Gery S, Gueller S, Chumakova K, Kawamata N, Liu L, Koeffler HP: Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders. Blood, 110(9): 3360-4, 2007
  3. Gery S, Virk RK, Chumakov K, Yu A, Koeffler HP: The clock gene Per2 links the circadian system to the estrogen receptor. Oncogene, 26(57): 7916-20, 2007
  4. Gery S, Koeffler HP: Transcription factors in hematopoietic malignancies. Curr. Opin. Genet. Dev., 17(1): 78-83, 2007
  5. Gery S, Koeffler HP: The role of circadian regulation in cancer. Cold Spring Harb. Symp. Quant. Biol., 72: 459-64, 2007
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