Joshua Goldhaber, MD

Director of Basic Research, Heart Institute

Associate Director, Coronary Intensive Care Unit, Cardiology

Email:joshua.goldhaber@cshs.org
Phone:(310) 423-8657
Fax:(310) 423-7637

Institute Affiliation

Heart Institute

Academic Appointments

Professor, Medicine

Awards and Activities

Dorothy and E. Phillip Lyon Chair in Laser Research2010
Alpha Omega Alpha2004
American Heart Association1985
Biophysical Society1990
Fellow, American College of Cardiology1990
Chair, Grant Review Committee, American Heart Association Western States Affiliate2003 - 2005
President, Western Society of Clniical Investigation2005 - 2006
President-Elect, Western Association of Physicians2011 - 2012
Program Committee, Heart Failure Society of America2011 - 2013

Research Focus

The Goldhaber lab's NIH and AHA-supported research is studying the regulation of cardiac excitation-contraction coupling in health and disease, with a particular focus on the effects of metabolic inhibition, ischemia and heart failure on sodium-calcium exchange. A new area of interst is the genesis of pacemaker activity in the sinus node. This has led to a new NIH-funded project to unravel the mysteries of the heart¿s natural pacemaker activity using laser scanning confocal microscopy, voltage mapping, and single cell electrophysiology using the patch clamp technique.

Research Contributions

Dr. Goldhaber was among the first to describe the effects of metabolic and oxidative stress on cardiac excitation-contraction coupling and calcium regulation. He was also a leader in the study of sodium-calcium exchange and its effects on excitation-contraction coupling in genetically modified mice.

Current investigations include:

-Cardiac Excitation-Contraction Coupling in Ischemic and Failing Myocytes
-Effects of Metabolic and Oxidative Stress on Cardiac Excitation-Contraction Coupling
-Role of Sodium-Calcium Exchanger in Excitation-Contraction Coupling
-Sinoatrial Node Pacemaking Dependence on Sodium-Calcium Exchange
-Structure-Function of the Sodium-Calcium Exchanger

Selected Publications

  1. Goldhaber JI, Hamilton MA: Role of inotropic agents in the treatment of heart failure. Circulation, 121(14): 1655-60, 2010
  2. Neco P, Rose B, Huynh N, Zhang R, Bridge JH, Philipson KD, Goldhaber JI: Sodium-calcium exchange is essential for effective triggering of calcium release in mouse heart. Biophys. J., 99(3): 755-64, 2010
  3. Larbig R, Torres N, Bridge JH, Goldhaber JI, Philipson KD: Activation of reverse Na+-Ca2+ exchange by the Na+ current augments the cardiac Ca2+ transient: evidence from NCX knockout mice. J. Physiol. (Lond.), 588(Pt 17): 3267-76, 2010
  4. Reuter H, Han T, Motter C, Philipson KD, Goldhaber JI: Mice overexpressing the cardiac sodium-calcium exchanger: defects in excitation-contraction coupling. J. Physiol. (Lond.), 554(Pt 3): 779-89, 2003
  5. Fukumoto GH, Lamp ST, Motter C, Bridge JH, Garfinkel A, Goldhaber JI: Metabolic inhibition alters subcellular calcium release patterns in rat ventricular myocytes: implications for defective excitation-contraction coupling during cardiac ischemia and failure. Circ. Res., 96(5): 551-7, 2005
  6. Chantawansri C, Huynh N, Yamanaka J, Garfinkel A, Lamp ST, Inoue M, Bridge JH, Goldhaber JI: Effect of metabolic inhibition on couplon behavior in rabbit ventricular myocytes. Biophys. J., 94(5): 1656-66, 2007

Lab Information