Leslie Raffel, MD

Director, CTSI, Cedars-Sinai Medical Center

Email:leslie.raffel@cshs.org
Phone:(310) 423-2703
Fax:(310) 423-0237

Academic Appointments

Professor, Pediatrics

Awards and Activities

Clinical Director, Medical Genetics Research Institute2013
Program Director, Cedars-Sinai General Clinical Research Center2008
Associate Editor: Genetics in Medicine1998 - 2006
Member, American Society of Human Genetics1984
Founding Fellow, American College of Medical Genetics1991

Research Focus

Delineation of the genetic basis of susceptibility to common adult-onset diseases, including type 2 (non-insulin dependent) diabetes mellitus and its complications, hypertension and coronary artery disease. Detailed physiological and biochemical studies are used to identify early changes related to a disorder and combined with large scale genotyping to identify genes that predispose to these conditions.

Research Contributions

Contributed to the understanding of the genes important in susceptibility to type 1 (insulin dependent) diabetes, including genes in the HLA region on chromosome 6, the insulin gene on chromosome 11, CTLA4 on chromosome 2, and the SUMO gene on chromosome 6. Helped establish that genetic factors influence diabetes and vascular related traits in the Hispanic population. Contributed to numerous GWAS studies identifying genetic loci involved in hypertension, insulin resistance and related conditions.

Current investigations include:

Family studies of cardiovascular risk factors in multiple ethnic groups. Questionnaire-based studies of attitudes about participating in genetics research. Pharmacogenetics of response to testosterone treatment.

Selected Publications

  1. Singh K, Moore S, Sandoval M, Balzer B, Frishberg D, Lewin S, Schreck R, Raffel L: Congenital Malignant Melanoma: A Case Report With Cytogenetic Studies. Am J Dermatopathol, , 2013
  2. Poland RE, Lesser IM, Wan YJ, Gertsik L, Yao J, Raffel LJ, Lin KM, Myers HF: Response to citalopram is not associated with SLC6A4 genotype in African-Americans and Caucasians with major depression. Life Sci., 92(20-21): 967-70, 2013
  3. Goodarzi MO, Guo X, Cui J, Jones MR, Haritunians T, Xiang AH, Chen YD, Taylor KD, Buchanan TA, Hsueh WA, Raffel LJ, Rotter JI: Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance. Diabetologia, 56(6): 1282-90, 2013
  4. Stambolian D, Wojciechowski R, Oexle K, Pirastu M, Li X, Raffel LJ, Cotch MF, Chew EY, Klein B, Klein R, Wong TY, Simpson CL, Klaver CC, van Duijn CM, Verhoeven VJ, Baird PN, Vitart V, Paterson AD, Mitchell P, Saw SM, Fossarello M, Kazmierkiewicz K, Murgia F, Portas L, Schache M, Richardson A, Xie J, Wang JJ, Rochtchina E, DCCT/EDIC Research Group, Viswanathan AC, Hayward C, Wright AF, Polasek O, Campbell H, Rudan I, Oostra BA, Uitterlinden AG, Hofman A, Rivadeneira F, Amin N, Karssen LC, Vingerling JR, Hosseini SM, Döring A, Bettecken T, Vatavuk Z, Gieger C, Wichmann HE, Wilson JF, Fleck B, Foster PJ, Topouzis F, McGuffin P, Sim X, Inouye M, Holliday EG, Attia J, Scott RJ, Rotter JI, Meitinger T, Bailey-Wilson JE: Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error. Hum. Mol. Genet., 22(13): 2754-64, 2013
  5. Coviello AD, Haring R, Wellons M, Vaidya D, Lehtimäki T, Keildson S, Lunetta KL, He C, Fornage M, Lagou V, Mangino M, Onland-Moret NC, Chen B, Eriksson J, Garcia M, Liu YM, Koster A, Lohman K, Lyytikäinen LP, Petersen AK, Prescott J, Stolk L, Vandenput L, Wood AR, Zhuang WV, Ruokonen A, Hartikainen AL, Pouta A, Bandinelli S, Biffar R, Brabant G, Cox DG, Chen Y, Cummings S, Ferrucci L, Gunter MJ, Hankinson SE, Martikainen H, Hofman A, Homuth G, Illig T, Jansson JO, Johnson AD, Karasik D, Karlsson M, Kettunen J, Kiel DP, Kraft P, Liu J, Ljunggren Ö, Lorentzon M, Maggio M, Markus MR, Mellström D, Miljkovic I, Mirel D, Nelson S, Morin Papunen L, Peeters PH, Prokopenko I, Raffel L, Reincke M, Reiner AP, Rexrode K, Rivadeneira F, Schwartz SM, Siscovick D, Soranzo N, Stöckl D, Tworoger S, Uitterlinden AG, van Gils CH, Vasan RS, Wichmann HE, Zhai G, Bhasin S, Bidlingmaier M, Chanock SJ, De Vivo I, Harris TB, Hunter DJ, Kähönen M, Liu S, Ouyang P, Spector TD, van der Schouw YT, Viikari J, Wallaschofski H, McCarthy MI, Frayling TM, Murray A, Franks S, Järvelin MR, de Jong FH, Raitakari O, Teumer A, Ohlsson C, Murabito JM, Perry JR: A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation. PLoS Genet., 8(7): e1002805, 2012
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