Lidia Szczepaniak, PhD

Research Scientist, Biomedical Imaging Research Institute

Research Scientist, Diabetes & Obesity Research Institute
Fax:(310) 248-8050

Academic Appointments

Associate Professor, Biomedical Sciences
Associate Professor, Medicine

Research Focus

The role of ectopic fat deposition in the development of overnutrition related obesity and associated complications such as type 2 diabetes and cardiomyopathy of diabetes. Investigating the concept of steatosis and lipotoxicity hypothesis.

Research Contributions

Developed, validated, and utilized a novel methodology involving proton magnetic resonance spectroscopy (1H MRS) to quantitatively and noninvasively measure fat in human organs, such as skeletal muscle, liver, pancreas, and the heart.

Current investigations include:

Determine the role of steatosis and lipotoxicity on pancreatic function in patients with obesity, Impaired Glucose Tolerance, and diabetes. Testing anti-steatotic action of Nebivolol treatment in pre-diabetic patients.

Selected Publications

  1. McGavock JM, Victor RG, Unger RH, Szczepaniak LS, American College of Physicians and the American Physiological Society: Adiposity of the heart, revisited. Ann. Intern. Med., 144(7): 517-24, 2006
  2. Lingvay I, Esser V, Legendre JL, Price AL, Wertz KM, Adams-Huet B, Zhang S, Unger RH, Szczepaniak LS: Noninvasive quantification of pancreatic fat in humans. J. Clin. Endocrinol. Metab., 94(10): 4070-6, 2009
  3. Lingvay I, Raskin P, Szczepaniak LS: The fatty hearts of patients with diabetes. Nat Rev Cardiol, 6(4): 268-9, 2009
  4. Szczepaniak LS, Victor RG, Orci L, Unger RH: Forgotten but not gone: the rediscovery of fatty heart, the most common unrecognized disease in America. Circ. Res., 101(8): 759-67, 2007
  5. McGavock JM, Lingvay I, Zib I, Tillery T, Salas N, Unger R, Levine BD, Raskin P, Victor RG, Szczepaniak LS: Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy study. Circulation, 116(10): 1170-5, 2007

Lab Information