M. William Audeh, MD, MS

Director, Cancer Clinical Quality Improvement, Hematology/Oncology

Medical Director, Outpatient Cancer Center, Cancer Institute

Medical Director, Wasserman Breast Cancer Risk Reduction Program, Cancer Institute

Email:william.audeh@cshs.org
Fax:(310) 423-4759

Institute Affiliation

Cancer Institute

Awards and Activities

American Cancer Society Clinical Fellowship in Oncology1986 - 1987
William R. Wilson Award for Excellence in Internal Medicine1982
Public Library of ScienceCurrent
Molecular OncologyCurrent
Nature Reviews Clinical OncologyCurrent
NatureCurrent
Gynecologic OncologyCurrent
American Society of Clinical Oncology1986
American Association of Cancer Research1994
American Society of Human Genetics1995

Research Focus

Treatment and prevention of breast cancer;using molecular profiling of breast, ovarian and colorectal cancers to determine personalized treatment strategies with targeted therapies; Clinical trials with genetically-targeted therapies such as PARP inhibitors against cancers with DNA repair defects, such as BRCA-mutated cancers; breast cancer risk reduction based on personalized risk assessment (genetics, hormonal and exposure history,diagnostic testing, etc) and appropriate risk reducing interventions.

Research Contributions

Principal Investigator for numerous clinical trials with targeted therapies in breast cancer; Principal Investigator at CSMC for first phase II clinical trials with genetically-targeted therapy in BRCA-mutated breast and ovarian cancers; first patient treated world wide at CSMC; initial strikingly positive results leading to further expansion of research into broader patient populations in international trials.

Current investigations include:

Translational Clinical Trials with targeted therapies; therapies targeting DNA repair defects in BRCA-mutated tumors regardless of organ of origin; neoadjuvant chemotherapy in triple negative breast cancer; therapies targeting tumor-dependent molecular pathways in patient-specific manner; development of breast cancer molecular profiling panel reflecting discrete biological subsets

Selected Publications

  1. Audeh MW: Letting the genome out of the bottle. N. Engl. J. Med., 358(20): 2184-5; author reply 2185, 2008
  2. Audeh MW: MDS and secondary AML: an evolutionary perspective. Cancer Treat. Res., 108: 267-78, 2001
  3. Gale RP, Park RE, Dubois RW, Anderson KC, Audeh WM, Bergsagel D, Jagannath S, Kyle RA, Oken MM, Perlman M, Rifkin RM, Stone MJ, Durie B: Delphi-panel analysis of appropriateness of high-dose therapy and bone marrow autotransplants in newly diagnosed multiple myeloma. Leuk. Lymphoma, 33(5-6): 511-9, 1999
  4. Audeh MW: Gastrointestinal cancer and the cystic fibrosis gene. N. Engl. J. Med., 333(2): 129-30, 1995
  5. Audeh MW, Jacobs CD, Davis TE, Carlson RW: A phase II trial of carbetimer for the treatment of colorectal cancer. A trial of the Northern California Oncology Group. Am. J. Clin. Oncol., 13(4): 324-6, 1990
  6. Audeh MW: Genetic predisposition testing for breast cancer. Cancer J Sci Am, 3(4): 254-5
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