Marla Dubinsky, MD

Director, PD Gastroenterology

Director, Pediatric Inflammatory Bowel Disease Program

Email:marla.dubinsky@cshs.org
Phone:310-423-7100
Fax:(310) 423-1402

Academic Appointments

Associate Professor, Pediatrics

Awards and Activities

international organization for IBD2012
Abe and Claire Levine Chair in Pediatric Inflammatory Bowel Disease2009
Lenny and Corrine Sands Clinical Investigator Award2007
Associate Editor American College of GastroenterologyCurrent
Section Editor: Inflammatory Bowel Disease2006 - 2011
Crohn's and Colitis Foundation of America2001
American College of Gastroenterolgy2001
American Gastroenterology Association2001
Medical Advisory Chair, CCFA Los Angeles Chapter2004 - 2008
Chair, IBD Committee, NASPGHAN2005 - 2007

Research Focus

Genetic and immune translational research in the field of inflammatory bowel disease. The laboratory is studying the natural history of the disease and investigating predictors of disease course. The research uncovers predictors of rapid disease progression with the goal of preventing complications by altering treatment plans.

Research Contributions

Research contributions have pioneered novel approaches to predicting disease course in children which impact treatments and disease outcome.

Current investigations include:

Serological immune markers in inflammatory bowel disease. Genetic associations with immune pathways. Prognostic information. Clinical and translational research.

Selected Publications

  1. Dubinsky MC, Mei L, Friedman M, Dhere T, Haritunians T, Hakonarson H, Kim C, Glessner J, Targan SR, McGovern DP, Taylor KD, Rotter JI: Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease. Inflamm. Bowel Dis., , 2009
  2. Dubinsky M: What is the role of serological markers in IBD? Pediatric and adult data. Dig Dis, 27(3): 259-68, 2009
  3. Dubinsky MC, Kugathasan S, Mei L, Picornell Y, Nebel J, Wrobel I, Quiros A, Silber G, Wahbeh G, Katzir L, Vasiliauskas E, Bahar R, Otley A, Mack D, Evans J, Rosh J, Hemker MO, Leleiko N, Crandall W, Langton C, Landers C, Taylor KD, Targan SR, Rotter JI, Markowitz J, Hyams J, Western Regional Pediatric IBD Research Alliance, Pediatric IBD Collaborative Research Group, Wisconsin Pediatric IBD Alliance: Increased immune reactivity predicts aggressive complicating Crohn's disease in children. Clin. Gastroenterol. Hepatol., 6(10): 1105-11, 2008
  4. Dubinsky M: Special issues in pediatric inflammatory bowel disease. World J. Gastroenterol., 14(3): 413-20, 2008
  5. Dubinsky MC: Clinical perspectives in Crohn's disease. Serologic and prognostic biomarkers: who, when, and how?. Reviews in gastroenterological disorders, 7 Suppl 2: S3-7, 2007
  6. Dubinsky MC, Wang D, Picornell Y, Wrobel I, Katzir L, Quiros A, Dutridge D, Wahbeh G, Silber G, Bahar R, Mengesha E, Targan SR, Taylor KD, Rotter JI, : IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease. Inflamm. Bowel Dis., 13(5): 511-5, 2007