Maya Koronyo-Hamaoui, PhD
Research Scientist, Maxine Dunitz Neurosurgical Institute
|Assistant Professor, Neurosurgery|
|Assistant Professor, Biomedical Sciences|
Awards and Activities
|DNRCA - CSMC Department of Neurosurgery Collaborative Research Award||2013 - 2014|
|BrightFocus Foundation Alzheimer's Research Award||2013|
|Pioneer in Medicine Award, the Brain Mapping Foundation (Retinal Imaging in AD)||2013|
|The primary award from the Coins for Alzheimer's Research Trust Fund||2012|
|The Alzheimer's Association International Conference (AAIC) 2012 Travel Award||2012|
|Best Research Poster Award & Prize - 1st & 2nd Annual Cedars-Sinai Research Days||2010 - 2011|
|Joan and Jaime Constantiner and the ISPG Travel Awards||2004 - 2005|
|Wolf Fund Excellence Award & Prize, the Sackler School of Medicine Faculty Dean, TAU||1996|
|Summa Cum Laude Master's Degree||1995|
|Cum Laude Bachelors in Science degree||1992|
|Dean's Excellence Award & Prize, the George S. Wise Life Sciences Faculty, Tel-Aviv University (TAU)||1992 - 1994|
|Editorial Board: Public Library of Science (PLoSONE)||Current|
|Member, Society for Neuroscience (SfN)||2006|
|Member: International Society to Advance Alzheimer Research and Treatment (ISTAART)||2007|
|Member: Association for Research in Vision and Ophthalmology (ARVO)||2011|
|Member, Society for Brain Mapping and Therapeutics (SBMT)||2011|
|Member, International Society of Neuroimmunology (ISNI)||2012|
Identifying and characterizing retinal pathologies specific to neurodegenerative disorders, especially Alzheimer's disease (AD). Investigation of the underling immunological mechanisms to battle AD.
* First-ever identification and characterization of hallmark pathology of Alzheimer's disease (AD), amyloid-ß protein (Aß) plaques, in the retina of human AD patients, and at early disease stages.
* Development of an innovative method to diagnose AD-pathology through the retina in live subjects; First-ever noninvasive optical retinal imaging of Aß deposits in live rodent models via curcumin labeling.
* First-ever noninvasive monitoring of individual Aß deposit dynamic appearance and clearance in live rodent models following immune-based therapy.
* The discovery that targeted ACE-overexpression in monocytes and microglia drastically attenuated the pathology associated with AD and retained cognitive function in murine models.
* Detection of novel molecular and cellular immune mechanisms essential for attenuating AD-like pathology; Development of immune-modulation therapeutic approaches to resist AD.
* Discovery of a link between genes in the glutamatergic system and genetic predisposition to complex psychiatric disorders, and especially anorexia nervosa.
* Identifying thymic involution as a co-morbidity factor in amyotrophic lateral sclerosis.
Current investigations include:
* Development of an effective immune-based therapy for Alzheimer's disease (AD)
* Investigation of the underlying immunological mechanisms involved in battling AD
* Identification and characterization of retinal pathology and visual dysfunctions specific to AD, in human patients and rodent models
* Investigation of the connection between the retina and the brain in neurodegenerative disorders, in terms of disease biomarkers, progression, and response to immunotherapy
* Investigation of the ability of iPS-derived as well as ACE-overexpressing macrophages to resist amyloid-ß protein
- Bernstein KE, Koronyo Y, Salumbides BC, Sheyn J, Pelissier L, Lopes DH, Shah KH, Bernstein EA, Fuchs DT, Yu JJ, Pham M, Black KL, Shen XZ, Fuchs S, Koronyo-Hamaoui M: Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive decline. J. Clin. Invest., , 2014
- Koronyo Y, Salumbides BC, Black KL, Koronyo-Hamaoui M: Alzheimer's disease in the retina: imaging retinal aß plaques for early diagnosis and therapy assessment. Neurodegener Dis, 10(1-4): 285-93, 2012
- Koronyo-Hamaoui M, Koronyo Y, Ljubimov AV, Miller CA, Ko MK, Black KL, Schwartz M, Farkas DL: Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model. Neuroimage, 54 Suppl 1: S204-17, 2010
- Koronyo-Hamaoui M, Ko MK, Koronyo Y, Azoulay D, Seksenyan A, Kunis G, Pham M, Bakhsheshian J, Rogeri P, Black KL, Farkas DL, Schwartz M: Attenuation of AD-like neuropathology by harnessing peripheral immune cells: local elevation of IL-10 and MMP-9. J. Neurochem., , 2009
- Butovsky O, Koronyo-Hamaoui M, Kunis G, Ophir E, Landa G, Cohen H, Schwartz M: Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc. Natl. Acad. Sci. U.S.A., 103(31): 11784-9, 2006
- Koronyo-Hamaoui M, Danziger Y, Frisch A, Stein D, Leor S, Laufer N, Carel C, Fennig S, Minoumi M, Apter A, Goldman B, Barkai G, Weizman A, Gak E: Association between anorexia nervosa and the hsKCa3 gene: a family-based and case control study. Mol. Psychiatry, 7(1): 82-5, 2002