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Ning-Ai Liu, MD, PhD
|Associate Clinical Professor, Medicine|
Awards and Activities
|Novartis Young Investigator Award||2003|
|NIH Clinical Scientist Development Award||2003|
|American Association of Clinical Endocrinologists||2002|
Using zebrafish (Danio rerio) as a vertebrate animal model, applying molecular, genetic, and pharmacological studies to understand pituitary development and diseases. Because principal components of genetic programs in fish and human are highly conserved, the studies will provide important clues to uncover genetic mysteries of pituitary disease in humans.
Using a live transgenic zebrafish model, findings on the ontogeny of corticotroph precursor cells provide novel mechanisms of molecular signal gradients required for morphogenesis of pituitary cell lineages.
Current investigations include:
Characterization of germline transgenic zebrafish at molecular, cellular and pharmacological levels to understand the development and function of pituitary gland. In vivo small molecule screen for potential new therapies for pituitary tumors.
- Liu NA, Ren M, Song J, RÃos Y, Wawrowsky K, Ben-Shlomo A, Lin S, Melmed S: In vivo time-lapse imaging delineates the zebrafish pituitary proopiomelanocortin lineage boundary regulated by FGF3 signal. Dev. Biol., 319(2): 192-200, 2008
- Ben-Shlomo A, Pichurin O, Barshop NJ, Wawrowsky KA, Taylor J, Culler MD, Chesnokova V, Liu NA, Melmed S: Selective regulation of somatostatin receptor subtype signaling: evidence for constitutive receptor activation. Mol. Endocrinol., 21(10): 2565-78, 2007
- Song J, Kim HJ, Gong Z, Liu NA, Lin S: Vhnf1 acts downstream of Bmp, Fgf, and RA signals to regulate endocrine beta cell development in zebrafish. Dev. Biol., 303(2): 561-75, 2006
- Liu NA, Liu Q, Wawrowsky K, Yang Z, Lin S, Melmed S: Prolactin receptor signaling mediates the osmotic response of embryonic zebrafish lactotrophs. Mol. Endocrinol., 20(4): 871-80, 2005
- Liu NA, Huang H, Yang Z, Herzog W, Hammerschmidt M, Lin S, Melmed S: Pituitary corticotroph ontogeny and regulation in transgenic zebrafish. Mol. Endocrinol., 17(5): 959-66, 2003
- Long Q, Huang H, Shafizadeh E, Liu N, Lin S: Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish. Nat. Cell Biol., 2(8): 549-52, 2000