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Patrick Lyden, MD
Director, Cedars Sinai Stroke Center, Neurology
Awards and Activities
|Best Doctors in America||2014|
|Carmen and Louis Warschaw Chair in Neurology||2009|
|Best Doctors in San Diego||2005|
|Elected Member, American Neurological Association||2003|
|Heart of Gold Honoree, American Heart Association San Diego Affiliate||2002|
|Elected Fellow, American Heart Association, Stroke Council||1998|
|Elected Fellow, American Academy of Neurology||1998|
|Peer Reviewer: Science Translational Medicine||Current|
|Editorial Board: Journal of Stroke and Cerebrovascular Diseases||Current|
|Editorial Board: Therapeutic Hypothermia and Temperature Management||Current|
|Editorial Board: Stroke||Current|
|Associate Editor: The International Journal of Stroke:||Current|
|Peer Reviewer: Lancet||Current|
|American Academy of Neurology||1987|
|Stroke Council, American Stroke Association||1988|
|American Neurological Association||1988|
|American Medical Association||1990|
|California Medical Association||1991|
|American Heart Association||1992|
|American Society of Neuroimaging||1999|
|Society for Neuroscience||1999|
To understand the mechanisms underlying the pathophysiology of ischemic stroke and translate our findings into potential stroke therapy.
A fellow of the American Academy of Neurology, Dr. Lyden has been funded by the National Institutes of Health, the American Heart Association, and the Veteran's Administration for over 30 years. Dr. Lyden has published more than 200 journal articles and abstracts, edited a textbook on stroke intervention, and made many presentations at national and international conferences.
He helped lead a pivotal trial of the only proven treatment for stroke - the clot-busting drug tissue plasminogen activator, or tPA - and shared a prestigious "CINE" award with the National Institute of Neurological Disorders and Stroke for producing and directing a training video that is now used around the world. Dubbed into Spanish, Portuguese, Italian, German, and Chinese, among other languages, the video has been viewed by more than 500,000 stroke nurses and physicians in North America alone.
A peer reviewer for more than 15 professional journals, he is on the editorial boards of Stroke, and the Journal of Stroke and Cerebrovascular Disease and is the Associate Editor of the International Journal of Stroke.
Current investigations include:
Thrombin and protease activated receptors, Stroke Research, Stem cell therapy in stroke. Hypothermia.
- Lyden P, Pereira B, Chen B, Zhao L, Lamb J, Lei IF, Rajput P: Direct thrombin inhibitor argatroban reduces stroke damage in 2 different models. Stroke, 45(3): 896-9, 2014
- Van Winkle JA, Chen B, Lei IF, Pereira B, Rajput PS, Lyden PD: Concurrent middle cerebral artery occlusion and intra-arterial drug infusion via ipsilateral common carotid artery catheter in the rat. J. Neurosci. Methods, 213(1): 63-9, 2012
- Wang Y, Zhao Z, Chow N, Rajput PS, Griffin JH, Lyden PD, Zlokovic BV: Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats. Stroke, 44(12): 3529-36, 2013
- Lyden PD: Hemorrhagic transformation during thrombolytic therapy and reperfusion: effects of age, blood pressure, and matrix metalloproteinases. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 22(4): 532-8, 2013
- Chen B, Van Winkle JA, Lyden PD, Brown JH, Purcell NH: PHLPP1 gene deletion protects the brain from ischemic injury. J. Cereb. Blood Flow Metab., 33(2): 196-204, 2012
- Chen B, Friedman B, Whitney MA, Winkle JA, Lei IF, Olson ES, Cheng Q, Pereira B, Zhao L, Tsien RY, Lyden PD: Thrombin activity associated with neuronal damage during acute focal ischemia. J. Neurosci., 32(22): 7622-31, 2012