Patrick Lyden, MD

Chair, Neurology

Director, Cedars Sinai Stroke Center, Neurology

Email:patrick.lyden@cshs.org
Phone:(310) 423-0894
Fax:(310) 248-8175

Awards and Activities

Best Doctors in America2014
Carmen and Louis Warschaw Chair in Neurology2009
Best Doctors in San Diego2005
Elected Member, American Neurological Association2003
Heart of Gold Honoree, American Heart Association San Diego Affiliate2002
Elected Fellow, American Heart Association, Stroke Council1998
Elected Fellow, American Academy of Neurology1998
Peer Reviewer: Science Translational MedicineCurrent
Editorial Board: Journal of Stroke and Cerebrovascular DiseasesCurrent
Editorial Board: Therapeutic Hypothermia and Temperature ManagementCurrent
Editorial Board: StrokeCurrent
Associate Editor: The International Journal of Stroke:Current
Peer Reviewer: LancetCurrent
American Academy of Neurology1987
Stroke Council, American Stroke Association1988
American Neurological Association1988
American Medical Association1990
California Medical Association1991
American Heart Association1992
American Society of Neuroimaging1999
Society for Neuroscience1999

Research Focus

To understand the mechanisms underlying the pathophysiology of ischemic stroke and translate our findings into potential stroke therapy.

Research Contributions

A fellow of the American Academy of Neurology, Dr. Lyden has been funded by the National Institutes of Health, the American Heart Association, and the Veteran's Administration for over 30 years. Dr. Lyden has published more than 200 journal articles and abstracts, edited a textbook on stroke intervention, and made many presentations at national and international conferences.
He helped lead a pivotal trial of the only proven treatment for stroke - the clot-busting drug tissue plasminogen activator, or tPA - and shared a prestigious "CINE" award with the National Institute of Neurological Disorders and Stroke for producing and directing a training video that is now used around the world. Dubbed into Spanish, Portuguese, Italian, German, and Chinese, among other languages, the video has been viewed by more than 500,000 stroke nurses and physicians in North America alone.
A peer reviewer for more than 15 professional journals, he is on the editorial boards of Stroke, and the Journal of Stroke and Cerebrovascular Disease and is the Associate Editor of the International Journal of Stroke.

Current investigations include:

Thrombin and protease activated receptors, Stroke Research, Stem cell therapy in stroke. Hypothermia.

Selected Publications

  1. Lyden P, Pereira B, Chen B, Zhao L, Lamb J, Lei IF, Rajput P: Direct thrombin inhibitor argatroban reduces stroke damage in 2 different models. Stroke, 45(3): 896-9, 2014
  2. Van Winkle JA, Chen B, Lei IF, Pereira B, Rajput PS, Lyden PD: Concurrent middle cerebral artery occlusion and intra-arterial drug infusion via ipsilateral common carotid artery catheter in the rat. J. Neurosci. Methods, 213(1): 63-9, 2012
  3. Wang Y, Zhao Z, Chow N, Rajput PS, Griffin JH, Lyden PD, Zlokovic BV: Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats. Stroke, 44(12): 3529-36, 2013
  4. Lyden PD: Hemorrhagic transformation during thrombolytic therapy and reperfusion: effects of age, blood pressure, and matrix metalloproteinases. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 22(4): 532-8, 2013
  5. Chen B, Van Winkle JA, Lyden PD, Brown JH, Purcell NH: PHLPP1 gene deletion protects the brain from ischemic injury. J. Cereb. Blood Flow Metab., 33(2): 196-204, 2012
  6. Chen B, Friedman B, Whitney MA, Winkle JA, Lei IF, Olson ES, Cheng Q, Pereira B, Zhao L, Tsien RY, Lyden PD: Thrombin activity associated with neuronal damage during acute focal ischemia. J. Neurosci., 32(22): 7622-31, 2012