Peng Shi, MD, PhD

Research Scientist, Neurology

Email:Peng.Shi@cshs.org
Phone:(310) 423-7373
Fax:(310) 248-8175

Awards and Activities

American Physiological Society2006
American Heart Association2008

Research Focus

Neuroinflammation and hypertension

Research Contributions

Anti-inflammation can significantly suppress blood pressure and sympathetic tone in hypertensive animals

Current investigations include:

1) to examine the effects of microglia on sympathetic outflow, neurohumoral release and pathophysiological changes associated with hypertension;
2) to characterize a distinctive molecular signature of microglial activation associated with hypertension;
3) to understand how microglial activation changes the progress of hypertension and its molecular basis.

Selected Publications

  1. Gonzalez-Villalobos RA, Shen XZ, Bernstein EA, Janjulia T, Taylor B, Giani JF, Blackwell WL, Shah KH, Shi PD, Fuchs S, Bernstein KE: Rediscovering ACE: novel insights into the many roles of the angiotensin-converting enzyme. J. Mol. Med., 91(10): 1143-54, 2013
  2. Shan Z, Zubcevic J, Shi P, Jun JY, Dong Y, Murça TM, Lamont GJ, Cuadra A, Yuan W, Qi Y, Li Q, Paton JF, Katovich MJ, Sumners C, Raizada MK: Chronic knockdown of the nucleus of the solitary tract AT1 receptors increases blood inflammatory-endothelial progenitor cell ratio and exacerbates hypertension in the spontaneously hypertensive rat. Hypertension, 61(6): 1328-33, 2013
  3. de Kloet AD, Krause EG, Shi PD, Zubcevic J, Raizada MK, Sumners C: Neuroimmune communication in hypertension and obesity: a new therapeutic angle?. Pharmacol. Ther., 138(3): 428-40, 2013
  4. Jiang N, Shi P, Desland F, Kitchen-Pareja MC, Sumners C: Interleukin-10 inhibits angiotensin II-induced decrease in neuronal potassium current. Am. J. Physiol., Cell Physiol., 304(8): C801-7, 2013
  5. Zubcevic J, Jun JY, Lamont G, Murça TM, Shi P, Yuan W, Lin F, Carvajal JM, Li Q, Sumners C, Raizada MK, Shan Z: Nucleus of the solitary tract (pro)renin receptor-mediated antihypertensive effect involves nuclear factor-¿B-cytokine signaling in the spontaneously hypertensive rat. Hypertension, 61(3): 622-7, 2013
  6. Colombari E, Colombari DS, Li H, Shi P, Dong Y, Jiang N, Raizada MK, Sumners C, Murphy D, Paton JF: Macrophage migration inhibitory factor in the paraventricular nucleus plays a major role in the sympathoexcitatory response to salt. Hypertension, 56(5): 956-63, 2010

Lab Information

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