Ravinder (Ravi) Abrol, PhD

Research Scientist, Gastroenterology

Research Scientist, Cancer Biology & Therapeutics Research

Email:abrolr@csmc.edu
Phone:(310) 423-0124

Awards and Activities

Adhoc Reviewer, Molecular and Integrative Signal Transduction Study Section, NIH CSR2014
Reviewer, Biological Chemistry, Biophysics, and Drug Discovery Study Section, NIH CSR2012
Travel Fellowship by NIH2010
Best Research Thesis Award, IIT Kanpur1995
Mariwala Trust Travel Scholarship1995
Academic Proficiency Award, IIT Kanpur1994
Jawahar Lal Nehru Summer Research Fellowship, JNCASR1994
Swaroop Ratan Memorial Scholarship for Academic Excellence, Swaroop Ratan Trust1992
Science Academic Award, University of Delhi1992
Editor: Journal of BiophysicsCurrent
Editor: International Journal of Chemical PhysicsCurrent
Associate Editor: Frontiers in PhysiologyCurrent
American Chemical Society2003
Protein Society2010
American Pancreatic Association2014

Research Focus

Development of methods in Computational Molecular Biology and their application to proteins of therapeutic interest to understand the structural basis of their function and signaling in normal and disease physiology with a focus on metabolic disorders, pancreatitis, and pancreatic cancer. Conformational view of G protein-coupled receptors' pleiotropic signaling. Translation of signaling hypotheses into rational therapeutic design.

Research Contributions

One of the leaders in de novo structure prediction of the multiple conformations of GPCRs; developed a novel and super-efficient conformational sampling algorithm for GPCR structure prediction; discovered several lead molecules for multiple protein targets with promising pre-clinical activity.

Current investigations include:

Method development for the prediction of active GPCR conformations with potentially biased coupling to G proteins, GRKs, and arrestins. Targeting gut GPCRs (including taste receptors among others) for diabetes. Probing the role of Ghrelin and its receptors in Cachexia during pancreatic cancer. Probing the role of PKD in pancreatitis for a rational design of therapeutics.

Selected Publications

  1. Bray JK, Abrol R, Goddard 3rd, Trzaskowski B, Scott CE: SuperBiHelix method for predicting the pleiotropic ensemble of G-protein-coupled receptor conformations. Proc. Natl. Acad. Sci. U.S.A., 111(1): E72-8, 2013
  2. Abrol R, Griffith AR, Bray JK, Goddard 3rd: Structure prediction of G protein-coupled receptors and their ensemble of functionally important conformations. Methods Mol. Biol., 914: 237-54, 2012
  3. Ramasamy S, Abrol R, Suloway CJ, Clemons Jr: The glove-like structure of the conserved membrane protein TatC provides insight into signal sequence recognition in twin-arginine translocation. Structure, 21(5): 777-88, 2013
  4. Berro R, Yasmeen A, Abrol R, Trzaskowski B, Abi-Habib S, Grunbeck A, Lascano D, Goddard 3rd, Klasse PJ, Sakmar TP, Moore JP: Use of G-protein-coupled and -uncoupled CCR5 receptors by CCR5 inhibitor-resistant and -sensitive human immunodeficiency virus type 1 variants. J. Virol., 87(12): 6569-81, 2013
  5. Kirkpatrick A, Heo J, Abrol R, Goddard 3rd: Predicted structure of agonist-bound glucagon-like peptide 1 receptor, a class B G protein-coupled receptor. Proc. Natl. Acad. Sci. U.S.A., 109(49): 19988-93, 2012
  6. Carpentier E, Greenbaum LA, Rochdi D, Abrol R, Goddard 3rd, Bichet DG, Bouvier M: Identification and characterization of an activating F229V substitution in the V2 vasopressin receptor in an infant with NSIAD. J. Am. Soc. Nephrol., 23(10): 1635-40, 2012
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