Roberta Gottlieb, MD

Research Scientist, Heart Institute

Email:Roberta.Gottlieb@cshs.org
Phone:(424) 315-2556

Institute Affiliation

Heart Institute

Awards and Activities

San Diego Women Who Mean Business2012
Fellow of the American Heart Association2010
Overall Winner, SD Tech Coast Angels Quick Pitch2009
Fellow of the International Society for Heart Research2009
Pew Scholar in Biomedical Sciences1997 - 2000
Frontiers in BiologyCurrent
Journal of Molecular and Cellular CardiologyCurrent
AutophagyCurrent
American Journal of Physiology: Heart and Circulatory PhysiologyCurrent
Biochemical Journal2004 - 2008
American Journal of Physiology: Cellular Physiology2003 - 2005
American Heart Association1994
International Society for Heart Research1996

Research Focus

Myocardial ischemia and cardioprotection. Focus is on mitochondria and autophagy. Using biochemistry, microscopy, and molecular physiology tools in cell, rodent, and porcine models to understand and mitigate ischemic injury with a goal of developing therapeutics for use in humans.

Research Contributions

Established the important role of autophagy in cardioprotection. Developed novel tools for studying autophagy. Pioneered the use of mitochondria-targeted recombinant proteins for cardiac therapy. First to report programmed cell death in the heart after ischemia and reperfusion. Established an animal model to understand how anthracyclines and neonatal viral infections can cause late-onset heart failure.

Current investigations include:

Autophagy, mitophagy and mitochondrial biogenesis in the heart. Impact of age and metabolic syndrome on autophagy and cardioprotection. Physiologic role of cardiac-resident stem cells in postnatal development. Therapeutic interventions to decrease risk of anthracycline-induced late-onset heart failure. Role of cardiac exosomes in tissue responses and viral infections.

Selected Publications

  1. Hernandez G, Thornton C, Stotland A, Lui D, Sin J, Ramil J, Magee N, Andres A, Quarato G, Carreira RS, Sayen MR, Wolkowicz R, Gottlieb RA: MitoTimer: A novel tool for monitoring mitochondrial turnover. Autophagy, 9(11): 1852-61, 2013
  2. Andres AM, Hernandez G, Lee P, Huang C, Ratliff EP, Sin J, Thornton CA, Damasco MV, Gottlieb RA: Mitophagy is Required for Acute Cardioprotection by Simvastatin. Antioxid. Redox Signal., , 2013
  3. Gottlieb RA, Mentzer Jr: Autophagy: an affair of the heart. Heart Fail Rev, 18(5): 575-84, 2013
  4. Jahania SM, Sengstock D, Vaitkevicius P, Andres A, Ito BR, Gottlieb RA, Mentzer Jr: Activation of the homeostatic intracellular repair response during cardiac surgery. J. Am. Coll. Surg., 216(4): 719-26; discussion 726-9, 2013
  5. Huang C, Andres AM, Ratliff EP, Hernandez G, Lee P, Gottlieb RA: Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1. PLoS ONE, 6(6): e20975, 2011
  6. Tabor-Godwin JM, Tsueng G, Sayen MR, Gottlieb RA, Feuer R: The role of autophagy during coxsackievirus infection of neural progenitor and stem cells. Autophagy, 8(6): 938-53, 2012

Lab Information

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