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Run Yu, PhD
Medical Director, Neuroendocrine Tumor Center
|Assistant Professor, Medicine|
Awards and Activities
|Genentech Clinical Fellows Travel Grant from Endocrine Society||2005|
|AACR-AstraZeneca Scholar-in-Training Award from the American Association for Cancer Research||2001|
|Knoll Thyroid Research Clinical Fellowship Award from the Endocrine Society||1999|
Regulation of pancreatic beta cell mass using mouse models and cell culture to understand the humoral and intrinsic beta cell factors that determine beta cell mass.
Showed that deletion of a cell cycle-regulating gene causes diminished beta cell mass. Found the mechanism is more beta cell apoptosis and senescence.
Current investigations include:
Mechanism of the apoptosis and senescence in beta cells. Role of DNA damage by deletion of a cell cycle-regulating gene.
- Wang Z, Moro E, Kovacs K, Yu R, Melmed S: Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes. Proc. Natl. Acad. Sci. U.S.A., 100(6): 3428-32, 2003
- Yu R, Cruz-Soto M, Li Calzi S, Hui H, Melmed S: Murine pituitary tumor-transforming gene functions as a securin protein in insulin-secreting cells. J. Endocrinol., 191(1): 45-53, 2006