Sandra Orsulic, PhD
Research Scientist, Women's Cancer Program, Cancer Institute
|Associate Professor, Obstetrics and Gynecology|
Awards and Activities
|Trainee-invited Distinguished Lecturer for 2014, The Wistar Institute||2014|
|Professor-in-Residence, OB/GYN, UCLA||2014|
|David Rimoin Teaching Excellence Award, Cedars-Sinai Graduate Program||2014|
|Co-Chair: AACR Special Conference on Advances in Ovarian Cancer Research||2013|
|Named Lecturership Speaker: John H. Blaffer Lecture Series||2006|
|Co-Chair: AACR Annual Meeting, Ovarian Cancer Session||2006|
|Named Lecturership Speaker: Helene Harris Memorial Trust International Forum on Ovarian Cancer||2005|
|Named Lecturership Speaker: Bulfinch Society Lecture Series||2005|
|Review Editor: Frontiers Cell and Developmental Biology||Current|
|Senior Editor: American Journal of Cancer Research||Current|
The mechanisms of ovarian cancer initiation; the role of microenvironment in cancer invasion and metastasis; the role of metabolic reprogramming in chromatin remodeling and cell differentiation in epithelial tumors and sarcomas.
Developed the first genetically defined mouse model of epithelial ovarian cancer that recapitulates human ovarian carcinoma development and progression (featured article in Nature Reviews Cancer: The First for Ovarian Cancer).
Current investigations include:
The genetic and epigenetic changes leading to the initiation and metastatic spread of ovarian cancer; molecular characterization of cooperating biochemical pathways in ovarian cancer; development of pre-clinical models for testing therapies that target specific biochemical pathways; and identification of biomarkers for early cancer detection and prediction of clinical outcomes.
- Cheon DJ, Orsulic S: Ten-gene biomarker panel: a new hope for ovarian cancer?. Biomark Med, 8(4): 523-6, 2014
- Cheon DJ, Tong Y, Sim MS, Dering J, Berel D, Cui X, Lester J, Beach JA, Tighiouart M, Walts AE, Karlan BY, Orsulic S: A collagen-remodeling gene signature regulated by TGF-ß signaling is associated with metastasis and poor survival in serous ovarian cancer. Clin. Cancer Res., 20(3): 711-23, 2013
- Gozo MC, Aspuria PJ, Cheon DJ, Walts AE, Berel D, Miura N, Karlan BY, Orsulic S: Foxc2 induces Wnt4 and Bmp4 expression during muscle regeneration and osteogenesis. Cell Death Differ., 20(8): 1031-42, 2013