Sandra Orsulic, PhD

Research Scientist, Women's Cancer Program, Cancer Institute

Email:sandra.orsulic@cshs.org
Phone:(310) 423-9546
Fax:(310) 423-9537

Institute Affiliation

Cancer Institute

Academic Appointments

Associate Professor, Obstetrics and Gynecology

Awards and Activities

Trainee-invited Distinguished Lecturer for 2014, The Wistar Institute2014
Professor-in-Residence, OB/GYN, UCLA2014
David Rimoin Teaching Excellence Award, Cedars-Sinai Graduate Program2014
Co-Chair: AACR Special Conference on Advances in Ovarian Cancer Research2013
Named Lecturership Speaker: John H. Blaffer Lecture Series2006
Co-Chair: AACR Annual Meeting, Ovarian Cancer Session2006
Named Lecturership Speaker: Helene Harris Memorial Trust International Forum on Ovarian Cancer2005
Named Lecturership Speaker: Bulfinch Society Lecture Series2005
Review Editor: Frontiers Cell and Developmental BiologyCurrent
Senior Editor: American Journal of Cancer ResearchCurrent

Research Focus

The mechanisms of ovarian cancer initiation; the role of microenvironment in cancer invasion and metastasis; the role of metabolic reprogramming in chromatin remodeling and cell differentiation in epithelial tumors and sarcomas.

Research Contributions

Developed the first genetically defined mouse model of epithelial ovarian cancer that recapitulates human ovarian carcinoma development and progression (featured article in Nature Reviews Cancer: The First for Ovarian Cancer).

Current investigations include:

The genetic and epigenetic changes leading to the initiation and metastatic spread of ovarian cancer; molecular characterization of cooperating biochemical pathways in ovarian cancer; development of pre-clinical models for testing therapies that target specific biochemical pathways; and identification of biomarkers for early cancer detection and prediction of clinical outcomes.

Selected Publications

  1. Cheon DJ, Orsulic S: Ten-gene biomarker panel: a new hope for ovarian cancer?. Biomark Med, 8(4): 523-6, 2014
  2. Cheon DJ, Tong Y, Sim MS, Dering J, Berel D, Cui X, Lester J, Beach JA, Tighiouart M, Walts AE, Karlan BY, Orsulic S: A collagen-remodeling gene signature regulated by TGF-ß signaling is associated with metastasis and poor survival in serous ovarian cancer. Clin. Cancer Res., 20(3): 711-23, 2013
  3. Gozo MC, Aspuria PJ, Cheon DJ, Walts AE, Berel D, Miura N, Karlan BY, Orsulic S: Foxc2 induces Wnt4 and Bmp4 expression during muscle regeneration and osteogenesis. Cell Death Differ., 20(8): 1031-42, 2013

Lab Information