Shervin Rabizadeh, MD, MBA

Physician, Pediatric Inflammatory Bowel Disease Program

Email:shervin.rabizadeh@cshs.org
Phone:(310) 423-7100
Fax:(310) 423-1402

Academic Appointments

Assistant Professor, Pediatrics

Awards and Activities

Crohn's and Colitis Foundation of America2009
American Gastroenterology Association2007
North American Society of Pediatric Gastroenterology, Hepatology and Nutrition2004
American Academy of Pediatrics2001

Research Focus

Relationship of bacteria, immunology, and inflammation as it pertains to diseases such as inflammatory bowel disease and colon cancer. The laboratory is studying models of bacteria induced intestinal inflammation to uncover key players in development of intestinal inflammation and cancer with the goal of enhancing diagnostic capabilities and treatment.

Research Contributions

Description of a specific bacteria induced intestinal inflammation and colon cancer murine model.

Current investigations include:

The role of innate immune markers and transcription factors in bacteria induced murine colitis.

Selected Publications

  1. Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, Huso DL, Brancati FL, Wick E, McAllister F, Housseau F, Pardoll DM, Sears CL: A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat. Med., 15(9): 1016-22, 2009
  2. Rabizadeh S, Rhee KJ, Wu S, Huso D, Gan CM, Golub JE, Wu X, Zhang M, Sears CL: Enterotoxigenic bacteroides fragilis: a potential instigator of colitis. Inflamm. Bowel Dis., 13(12): 1475-83, 2007
  3. Goodwin AC, Destefano Shields CE, Wu S, Huso DL, Wu X, Murray-Stewart TR, Hacker-Prietz A, Rabizadeh S, Woster PM, Sears CL, Casero Jr: Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis. Proc. Natl. Acad. Sci. U.S.A., 108(37): 15354-9, 2011
  4. Rhee KJ, Wu S, Wu X, Huso DL, Karim B, Franco AA, Rabizadeh S, Golub JE, Mathews LE, Shin J, Sartor RB, Golenbock D, Hamad AR, Gan CM, Housseau F, Sears CL: Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice. Infect. Immun., 77(4): 1708-18, 2009
  5. Lowe EL, Crother TR, Rabizadeh S, Hu B, Wang H, Chen S, Shimada K, Wong MH, Michelsen KS, Arditi M: Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer. PLoS ONE, 5(9): e13027, 2010
  6. Soliman A, Michelsen KS, Karahashi H, Lu J, Meng FJ, Qu X, Crother TR, Rabizadeh S, Chen S, Caplan MS, Arditi M, Jilling T: Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis. PLoS ONE, 5(10): e15044, 2010