TingTing Hong, MD, PhD
Research Scientist, Cardiology
|Assistant Professor, Medicine|
Awards and Activities
|UCSF Dean's Postdoctoral Prize Lecture||2012|
|NIH K99/R00 Fellow-to-faculty Award||2012|
Cardiomyocyte cell biology and molecular mechanisms of heart failure progression. We focus on cardiac membrane organization and function, with particular interests on T-tubule microdomain function and regulation.
Defined molecular mechanisms and function of BIN1-induced membrane structures and subdomains within cardiac T-tubules.
Current investigations include:
Human and mouse model of heart failure. BIN1 and cytoskeleton-based mechanisms of T-tubule microdomains in intracellular calcium signaling, and mechanisms of T-tubule microdomain turnover and remodeling during heart failure.
- Hong T, Yang H, Zhang SS, Cho HC, Kalashnikova M, Sun B, Zhang H, Bhargava A, Grabe M, Olgin J, Gorelik J, Marbán E, Jan LY, Shaw RM: Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia. Nat. Med., 20(6): 624-32, 2014
- Smyth JW, Vogan JM, Buch PJ, Zhang SS, Fong TS, Hong TT, Shaw RM: Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane. Circ. Res., 110(7): 978-89, 2012
- Hong TT, Cogswell R, James CA, Kang G, Pullinger CR, Malloy MJ, Kane JP, Wojciak J, Calkins H, Scheinman MM, Tseng ZH, Ganz P, De Marco T, Judge DP, Shaw RM: Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy. Heart rhythm : the official journal of the Heart Rhythm Society, 9(6): 961-7, 2012
- Hong TT, Smyth JW, Chu KY, Vogan JM, Fong TS, Jensen BC, Fang K, Halushka MK, Russell SD, Colecraft H, Hoopes CW, Ocorr K, Chi NC, Shaw RM: BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes. Heart rhythm : the official journal of the Heart Rhythm Society, 9(5): 812-20, 2011
- Hong TT, Smyth JW, Gao D, Chu KY, Vogan JM, Fong TS, Jensen BC, Colecraft HM, Shaw RM: BIN1 localizes the L-type calcium channel to cardiac T-tubules. PLoS Biol., 8(2): e1000312, 2010
- Smyth JW, Hong TT, Gao D, Vogan JM, Jensen BC, Fong TS, Simpson PC, Stainier DY, Chi NC, Shaw RM: Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium. J. Clin. Invest., 120(1): 266-79, 2009