Tyler Pierson, MD, PhD

Staff Physician, PD Neurology

Phone:(310) 248-8558
Fax:(310) 248-8066

Institute Affiliation

Regenerative Medicine Institute

Academic Appointments

Clinical Instructor, Pediatrics

Awards and Activities

Fashion Industries Guild Endowed Fellowship in Pediatric Neuromuscular Diseases2012
Team Science Award from the Society for Clinical and Translational Science (SCTS)2011
National Human Genome Research Institute Merit Award2011
Child Neurology Society2006
American Society of Gene and Cell Therapy2008
American Academy of Neurology2008

Research Focus

Identification and diagnosis of rare pediatric neurogenetic disorders in the clinic and the laboratory with genomics and stem-cell biology. Further investigations regarding the modeling and treatment of rare pediatric neurogenetic disorders in the laboratory. Implementation of gene and stem-cell based therapies for rare neurogenetic disorders.

Research Contributions

Expert in clinical and research application of genomics and rare neurological disorders

Current investigations include:

Development of inducible gene regulation system for use in the central nervous system. Investigations of molecular and cellular etiologies of SPG11 with induced pluripotent stem cells. In vitro modeling of rare neurogenetic disorders with induced pluripotent stem cells.

Selected Publications

  1. Yuan H, Hansen KB, Zhang J, Pierson TM, Markello TC, Fajardo KV, Holloman CM, Golas G, Adams DR, Boerkoel CF, Gahl WA, Traynelis SF: Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy. Nat Commun, 5: 3251, 2014
  2. Pierson TM, Adams DA, Markello T, Golas G, Yang S, Sincan M, Simeonov DR, Fuentes Fajardo K, Hansen NF, Cherukuri PF, Cruz P, Teer JK, Mullikin JC, NISC Comparative Sequencing Program, Boerkoel CF, Gahl WA, Tifft CJ: Exome sequencing as a diagnostic tool in a case of undiagnosed juvenile-onset GM1-gangliosidosis. Neurology, 79(2): 123-6, 2012
  3. Pierson TM, Adams D, Bonn F, Martinelli P, Cherukuri PF, Teer JK, Hansen NF, Cruz P, Mullikin For The Nisc Comparative Sequencing Program JC, Blakesley RW, Golas G, Kwan J, Sandler A, Fuentes Fajardo K, Markello T, Tifft C, Blackstone C, Rugarli EI, Langer T, Gahl WA, Toro C: Whole-exome sequencing identifies homozygous AFG3L2 mutations in a spastic ataxia-neuropathy syndrome linked to mitochondrial m-AAA proteases. PLoS Genet., 7(10): e1002325, 2011
  4. Gahl WA, Markello TC, Toro C, Fajardo KF, Sincan M, Gill F, Carlson-Donohoe H, Gropman A, Pierson TM, Golas G, Wolfe L, Groden C, Godfrey R, Nehrebecky M, Wahl C, Landis DM, Yang S, Madeo A, Mullikin JC, Boerkoel CF, Tifft CJ, Adams D: The National Institutes of Health Undiagnosed Diseases Program: insights into rare diseases. Genet. Med., 14(1): 51-9, 2011
  5. Pierson TM, Bonnemann CG, Finkel RS, Bunin N, Tennekoon GI: Umbilical cord blood transplantation for juvenile metachromatic leukodystrophy. Ann. Neurol., 64(5): 583-7, 2008
  6. Pierson TM, Wang Y, DeMayo FJ, Matzuk MM, Tsai SY, Omalley BW: Regulable expression of inhibin A in wild-type and inhibin alpha null mice. Mol. Endocrinol., 14(7): 1075-85, 2000

Lab Information

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