Wen-Chin Huang, PhD

Research Scientist, Hematology/Oncology

Phone:(310) 423-7378
Fax:(310) 423-8543

Academic Appointments

Assistant Professor, Medicine

Awards and Activities

Georgia Cancer Coalition, Cancer Research Awards2009
Department of Defense, Idea-Development Award -New Investigator2008
American Association for Cancer Research, Scholar-in-Training Award2006
Editor: American Journal of Cancer BiologyCurrent
Editor: Journal of Cancer Research and TreatmentCurrent
Active Membership of AACR2006

Research Focus

To reveal and investigate the molecular signaling mechanism and targeting of lethal prostate cancer progression and metastasis.

Research Contributions

Developed a monoclonal antibody against human ß2-microglobulin (ß2M) to target ß2M and the ß2M signaling axis in prostate cancer cells. The pre-clinical results showed that ß2M monoclonal antibody significantly induced programmed cell death in prostate cancer and cancer stem cells but did not affect normal prostate cells.

Current investigations include:

1) Exploring the biological activity and anti-cancer efficacy of anti-ß2M monoclonal antibody as a novel immunologic therapy in prostate cancer; 2) Determining the pleiotropic functions of ß2M in prostate cancer stem cells; and 3) Investigating the roles of a new identified lipogenic transcription factor, sterol regulatory element-binding protein-1 (SREBP-1), which is controlling fatty acid and lipid metabolism, in prostate cancer survival, progression and metastasis.

Selected Publications

  1. Huang WC, Li X, Liu J, Lin J, Chung LW: Activation of androgen receptor, lipogenesis, and oxidative stress converged by SREBP-1 is responsible for regulating growth and progression of prostate cancer cells. Mol. Cancer Res., 10(1): 133-42, 2011
  2. Josson S, Nomura T, Lin JT, Huang WC, Wu D, Zhau HE, Zayzafoon M, Weizmann MN, Gururajan M, Chung LW: ß2-microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells. Cancer Res., 71(7): 2600-10, 2011
  3. Huang WC, Zhau HE, Chung LW: Androgen receptor survival signaling is blocked by anti-beta2-microglobulin monoclonal antibody via a MAPK/lipogenic pathway in human prostate cancer cells. The Journal of biological chemistry, 285(11): 7947-56, 2010
  4. Huang WC, Havel JJ, Zhau HE, Qian WP, Lue HW, Chu CY, Nomura T, Chung LW: Beta2-microglobulin signaling blockade inhibited androgen receptor axis and caused apoptosis in human prostate cancer cells. Clin. Cancer Res., 14(17): 5341-7, 2008