Xiao Shen, MD

Research Scientist, Immunology Research

Email:Xiao.Shen@cshs.org
Phone:(310) 423-2110
Fax:(310) 423-7331

Academic Appointments

Assistant Professor, Biomedical Sciences

Awards and Activities

Reviewer: Regulatory PeptidesCurrent
Reviewer: PLoS ONECurrent
Reviewer: Clinical ScienceCurrent
Reviewer: Journal of the Renin-Angiotensin-Aldosterone SystemCurrent
American Heart Ass'n and American Stroke Ass'n.2006
The Society for Leukocyte Biology2006
The American Physiology Society2013

Research Focus

Macrophages and dendritic cells are the bridge connecting innate immunity and adaptive immunity. The lab is investigating the mechanisms that regulate these cells in two levels: the differentiation and maturation of these cells and antigen presentation. Also, we are characterizing the myeloid cells in cardiovascular diseases, such as hypertension.

Research Contributions

Unveiled that ACE is actively involved in aspects of immunology: identified that ACE is the carboxypeptidase involved in editing MHC class I peptides; discovered that ACE is required for the homeostasis of myelopoiesis through metabolizing a variety of bioactive peptides; ACE regulates aspects of myelopoiesis, such as myelo-proliferation, myelo-differentiation and macrophage functional maturation.

Current investigations include:

ACE in antigen presentation
ACE in myeloid cell differentiation and functional maturation
Development of myeloid-derived suppressor cells
Immune responses in hypertension

Selected Publications

  1. Shen XZ, Billet S, Lin C, Okwan-Duodu D, Chen X, Lukacher AE, Bernstein KE: The carboxypeptidase ACE shapes the MHC class I peptide repertoire. Nat. Immunol., 12(11): 1078-85, 2011
  2. Shen XZ, Bernstein KE: The peptide network regulated by angiotensin converting enzyme (ACE) in hematopoiesis. Cell Cycle, 10(9): 1363-9, 2011
  3. Lin C, Datta V, Okwan-Duodu D, Chen X, Fuchs S, Alsabeh R, Billet S, Bernstein KE, Shen XZ: Angiotensin-converting enzyme is required for normal myelopoiesis. FASEB J., 25(4): 1145-55, 2010
  4. Shen XZ, Lukacher AE, Billet S, Williams IR, Bernstein KE: Expression of angiotensin-converting enzyme changes major histocompatibility complex class I peptide presentation by modifying C termini of peptide precursors. J. Biol. Chem., 283(15): 9957-65, 2008
  5. Shen XZ, Li P, Weiss D, Fuchs S, Xiao HD, Adams JA, Williams IR, Capecchi MR, Taylor WR, Bernstein KE: Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma. Am. J. Pathol., 170(6): 2122-34, 2007
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