Xiaojiang Cui, PhD
Research Scientist, Womens Cancer Program, Cancer Institute
|Associate Professor, Surgery|
Awards and Activities
|Presentation Award: Annual Dan L. Duncan Cancer Center Retreat, Baylor College of Medicine||2006|
|NCI: Breast Cancer SPORE Career Development Award||2004|
|First Place Abstract: Annual Dan L. Duncan Cancer Center Retreat, Baylor College of Medicine||2003|
|Postdoctoral Training Award: U.S. Department of Defense Breast Cancer Research Program||2001|
|Editorial Board Member: Journal of Analytical Oncology||Current|
|American Association for Cancer Research||2000|
(1) Decipher biochemical and signaling mechanisms of cancer metastasis and therapeutic resistance; (2) Utilize these mechanisms to identify potential targets for therapeutic interventions; (3) Develop effective anticancer therapies based on these targets.
Uncovered mechanisms for crosstalk between IGFs and progesterone. Discovered critical biomarkers for basal-like breast cancer.
Current investigations include:
Molecualr mechanisms of basal-like breast cancer development and progression. Cancer brain metastasis. Transgenic models of breast cancer. Mammary stem cells.
- Wang J, Ray PS, Sim MS, Zhou XZ, Lu KP, Lee AV, Lin X, Bagaria SP, Giuliano AE, Cui X: FOXC1 regulates the functions of human basal-like breast cancer cells by activating NF-¿B signaling. Oncogene, 31(45): 4798-802, 2012
- Qu Y, Wang J, Ray PS, Guo H, Huang J, Shin-Sim M, Bukoye BA, Liu B, Lee AV, Lin X, Huang P, Martens JW, Giuliano AE, Zhang N, Cheng NH, Cui X: Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-¿B signaling. J. Clin. Invest., 121(1): 212-25, 2010
- Ray PS, Wang J, Qu Y, Sim MS, Shamonki J, Bagaria SP, Ye X, Liu B, Elashoff D, Hoon DS, Walter MA, Martens JW, Richardson AL, Giuliano AE, Cui X: FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer. Cancer Res., 70(10): 3870-6, 2010
- Wang J, Kuiatse I, Lee AV, Pan J, Giuliano A, Cui X: Sustained c-Jun-NH2-kinase activity promotes epithelial-mesenchymal transition, invasion, and survival of breast cancer cells by regulating extracellular signal-regulated kinase activation. Mol. Cancer Res., 8(2): 266-77, 2010