Xiaojiang Cui, PhD

Research Scientist, Womens Cancer Program, Cancer Institute

Email:Xiaojiang.cui@cshs.org
Phone:(310) 423-7437
Fax:(310) 423-9537

Institute Affiliation

Cancer Institute

Academic Appointments

Associate Professor, Surgery

Awards and Activities

Presentation Award: Annual Dan L. Duncan Cancer Center Retreat, Baylor College of Medicine2006
NCI: Breast Cancer SPORE Career Development Award2004
First Place Abstract: Annual Dan L. Duncan Cancer Center Retreat, Baylor College of Medicine2003
Postdoctoral Training Award: U.S. Department of Defense Breast Cancer Research Program2001
Editorial Board Member: Journal of Analytical OncologyCurrent
Endocrine Society2000
American Association for Cancer Research2000

Research Focus

(1) Decipher biochemical and signaling mechanisms of cancer metastasis and therapeutic resistance; (2) Utilize these mechanisms to identify potential targets for therapeutic interventions; (3) Develop effective anticancer therapies based on these targets.

Research Contributions

Uncovered mechanisms for crosstalk between IGFs and progesterone. Discovered critical biomarkers for basal-like breast cancer.

Current investigations include:

Molecualr mechanisms of basal-like breast cancer development and progression. Cancer brain metastasis. Transgenic models of breast cancer. Mammary stem cells.

Selected Publications

  1. Wang J, Ray PS, Sim MS, Zhou XZ, Lu KP, Lee AV, Lin X, Bagaria SP, Giuliano AE, Cui X: FOXC1 regulates the functions of human basal-like breast cancer cells by activating NF-¿B signaling. Oncogene, 31(45): 4798-802, 2012
  2. Qu Y, Wang J, Ray PS, Guo H, Huang J, Shin-Sim M, Bukoye BA, Liu B, Lee AV, Lin X, Huang P, Martens JW, Giuliano AE, Zhang N, Cheng NH, Cui X: Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-¿B signaling. J. Clin. Invest., 121(1): 212-25, 2010
  3. Ray PS, Wang J, Qu Y, Sim MS, Shamonki J, Bagaria SP, Ye X, Liu B, Elashoff D, Hoon DS, Walter MA, Martens JW, Richardson AL, Giuliano AE, Cui X: FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer. Cancer Res., 70(10): 3870-6, 2010
  4. Wang J, Kuiatse I, Lee AV, Pan J, Giuliano A, Cui X: Sustained c-Jun-NH2-kinase activity promotes epithelial-mesenchymal transition, invasion, and survival of breast cancer cells by regulating extracellular signal-regulated kinase activation. Mol. Cancer Res., 8(2): 266-77, 2010

Lab Information