IBD Publications

Patient Population Studies

Combination of genetic and quantitative serological immune markers are associated with complicated Crohn's disease behavior. Lichtenstein GR, Targan SR, Dubinsky MC, Rotter JI, Barken DM, Princen F, Carroll S, Brown M, Stachelski J, Chuang E, Landers CJ, Stempak JM, Singh S, Silverberg MS. Inflamm Bowel Dis. 2011 Dec;17(12):2488-96. doi: 10.1002/ibd.21661. Epub 2011 Mar 9.

Genetic predictors of medically refractory ulcerative colitis. Haritunians T, Taylor KD, Targan SR, Dubinsky M, Ippoliti A, Kwon S, Guo X, Melmed GY, Berel D, Mengesha E, Psaty BM, Glazer NL, Vasiliauskas EA, Rotter JI, Fleshner PR, McGovern DP. Inflamm Bowel Dis. 2010 Nov;16(11):1830-40. doi: 10.1002/ibd.21293. PMID: 20848476 [PubMed - indexed for MEDLINE]

Genome-wide association identifies multiple ulcerative colitis susceptibility loci. McGovern DP, Gardet A, Törkvist L, Goyette P, Essers J, Taylor KD, Neale BM, Ong RT, Lagacé C, Li C, Green T, Stevens CR, Beauchamp C, Fleshner PR, Carlson M, D'Amato M, Halfvarson J, Hibberd ML, Lördal M, Padyukov L, Andriulli A, Colombo E, Latiano A, Palmieri O, Bernard EJ, Deslandres C, Hommes DW, de Jong DJ, Stokkers PC, Weersma RK; NIDDK IBD Genetics Consortium, Sharma Y, Silverberg MS, Cho JH, Wu J, Roeder K, Brant SR, Schumm LP, Duerr RH, Dubinsky MC, Glazer NL, Haritunians T, Ippoliti A, Melmed GY, Siscovick DS, Vasiliauskas EA, Targan SR, Annese V, Wijmenga C, Pettersson S, Rotter JI, Xavier RJ, Daly MJ, Rioux JD, Seielstad M. Nat Genet. 2010 Apr;42(4):332-7. doi: 10.1038/ng.549. Epub 2010 Mar 14. Erratum in: Nat Genet. 2011 Apr;43(4):388.

Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease. Dubinsky MC, Mei L, Friedman M, Dhere T, Haritunians T, Hakonarson H, Kim C, Glessner J, Targan SR, McGovern DP, Taylor KD, Rotter JI. Inflamm Bowel Dis. 2010 Aug;16(8):1357-66. doi: 10.1002/ibd.21174.

Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease. McGovern DP, Rotter JI, Mei L, Haritunians T, Landers C, Derkowski C, Dutridge D, Dubinsky M, Ippoliti A, Vasiliauskas E, Mengesha E, King L, Pressman S, Targan SR, Taylor KD.
Inflamm Bowel Dis. 2009 Jun;15(6):883-9. doi: 10.1002/ibd.20855.

Linkage of Crohn's disease-related serological phenotypes: NFKB1 haplotypes are associated with anti-CBir1 and ASCA, and show reduced NF-kappaB activation. Takedatsu H, Taylor KD, Mei L, McGovern DP, Landers CJ, Gonsky R, Cong Y, Vasiliauskas EA, Ippoliti A, Elson CO, Rotter JI, Targan SR. Gut. 2009 Jan;58(1):60-7. doi: 10.1136/gut.2008.156422. Epub 2008 Oct 2. 

Increased immune reactivity predicts aggressive complicating Crohn's disease in children. Dubinsky MC, Kugathasan S, Mei L, Picornell Y, Nebel J, Wrobel I, Quiros A, Silber G, Wahbeh G, Katzir L, Vasiliauskas E, Bahar R, Otley A, Mack D, Evans J, Rosh J, Hemker MO, Leleiko N, Crandall W, Langton C, Landers C, Taylor KD, Targan SR, Rotter JI, Markowitz J, Hyams J; Western Regional Pediatric IBD Research Alliance; Pediatric IBD Collaborative Research Group; Wisconsin Pediatric IBD Alliance. Clin Gastroenterol Hepatol. 2008 Oct;6(10): 1105-11. doi: 10.1016/j.cgh.2008.04.032. Epub 2008 Jul 10. 

 

Target-Specific Studies

Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis. Barrett R, Zhang X, Koon HW, Vu M, Chang JY, Yeager N, Nguyen MA, Michelsen KS, Berel D, Pothoulakis C, Targan SR, Shih DQ. Am J Pathol. 2012 Feb;180(2):636-49. doi: 10.1016/j.ajpath.2011.10.026. Epub 2011 Dec 2.

Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis. Shih DQ, Barrett R, Zhang X, Yeager N, Koon HW, Phaosawasdi P, Song Y, Ko B, Wong MH, Michelsen KS, Martins G, Pothoulakis C, Targan SR. PLoS One. 2011 Jan 11;6(1):e16090. doi: 10.1371/journal.pone.0016090.

TL1A selectively enhances IL-12/IL-18-induced NK cell cytotoxicity against NK-resistant tumor targets. Heidemann SC, Chavez V, Landers CJ, Kucharzik T, Prehn JL, Targan SR. J ClinImmunol. 2010 Jul;30(4):531-8. doi: 10.1007/s10875-010-9382-9. Epub 2010 Mar 27.

IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein. Michelsen KS, Thomas LS, Taylor KD, Yu QT, Mei L, Landers CJ, Derkowski C, McGovern DP, Rotter JI, Targan SR. PLoS One. 2009;4(3):e4719. doi: 10.1371/journal.pone.0004719. Epub 2009 Mar 5.

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