Lab Members

Assistant Professor Shuang Chen

Shuang Chen, MD, PhD

Assistant Professor, Principal Investigator Email: shuang.chen@cshs.org

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Shuang Chen, MD, PhD, received her doctorate in cardiovascular physiology at Hebei Medical University in China. After postdoctoral studies at Harbor-UCLA, investigating the nitric oxide and GABA signal transduction in the somatosympathetic reflexes and their cardiovascular control mechanisms, Chen joined the lab of Moshe Arditi, MD, studying varying aspects of innate immunity, infection and atherosclerosis. She has been an assistant professor with the departments of Pediatrics and Biomedical Sciences at Cedars-Sinai since January 2010. Chen has received an American Heart Association Grant-in-Aid award and recently was awarded an R01 from the National Institutes of Health to investigate the role of IL-17 and the NLRP3 inflammasome activation in atherogenesis. Chen's focus is on understanding mechanisms of vascular inflammation, atherosclerosis and Kawasaki disease and on discovering new and more efficacious treatments for patients with these disorders.

Arditi Laboratory Cedars-Sinai Assistant Professor Timothy R. Crother, PhD

Timothy R. Crother, PhD

Assistant Professor Email: timothy.crother@cshs.org

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Timothy R. Crother, PhD, received his doctorate from Indiana University in molecular, cellular and developmental biology. After postdoctoral studies at UCLA, investigating the pathogenesis of Borrelia burgdorferi (the causative agent of Lyme disease), Crother joined the lab of Moshe Arditi, MD, studying varying aspects of innate immunity, pulmonary infections and asthma. Currently an assistant professor of research, Crother continues his investigations in close association with the Arditi Laboratory.

Arditi Laboratory Cedars-Sinai Assistant Professor Kenichi Shimada, PhD

Kenichi Shimada, PhD

Assistant Professor Email: kenichi.shimada@cshs.org

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Kenichi Shimada, PhD, received his doctorate in microbiology and immunology at Kitasato University in Japan. He joined the Arditi Laboratory in 2006 and studies host defenses against pathogens, innate immunity and immune regulation. Shimada made the seminal observation that during apoptosis, oxidized mitochondrial DNA is released and binds to cytosolic NLRP3 to activate it for IL-1b production (Immunity, 2012), and oxidized mitochondrial DNA damage accelerates atherosclerosis (Circ Res, 2016). Shimada is now investigating the role of mitochondria biogenesis in mechanical ventilator-induced acute lung injury, the role of Rip2 and Th17 in Chlamydia pneumoniae infections and the role of autophagy in myocardial infarction.

Michifumi Yamashita, MD, PhD

Michifumi Yamashita, MD, PhD

Assistant Professor Email: michifumi.yamashita@cshs.org

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Michifumi Yamashita, MD, PhD, is an assistant professor of Pathology and a physician-scientist in renal pathology. He completed his postdoctoral training in the laboratories of Ganes C. Sen, PhD, Department of Molecular Genetics, Cleveland Clinic, and Steven N. Emancipator, MD, Department of Pathology, Case Western Reserve University, Cleveland. His research revealed the essential kinases for TLR3: EGF receptor and Src phosphorylates, the specific tyrosine residues of TLR3. After clinical fellowship in renal pathology at Brigham and Women's Hospital/Harvard Medical School, Yamashita joined the faculty at Cedars-Sinai in 2016. His research now focuses on understanding the role of EGFR in TLR-mediated injury in glomerulonephritis, a form of vasculitis in kidney glomeruli.

Vikram Anand, MD, PhD

Vikram Anand, MD, PhD

Assistant Professor Email: vikram.anand@cshs.org

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Vikram Anand, MD, PhD, received his medical degree and PhD from the UCLA School of Medicine through the combined Medical Scientist Training Program. For his doctoral work, Anand investigated intracellular protein transport. He completed his residency in pediatrics at UCLA, followed by a fellowship in pediatric infectious diseases at Children's Hospital Los Angeles. During his fellowship, Anand investigated TNF alpha receptor involvement in a mouse model of inflammatory bowel disease. Now he is focused on studying the interaction of microorganisms residing in a host.

Arditi Laboratory Cedars-Sinai Postdoctoral Researcher Jargalsaikahn Dagvadorj, PhD

Jargalsaikahn Dagvadorj, PhD

Research Scientist Email: jargalsaikhan.dagvadorj@cshs.org

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Jargalsaikahn Dagvadorj, PhD, received his doctorate at Aichi Medical University, Japan. He joined the Arditi Laboratory as a postdoctoral trainee and investigated the functions and regulations of bacterial lipopolysaccharide-mediated Toll-like receptor 4 (TLR4) activation during the early phase of immune response and acute lung injury (ALI). The study described that during the ALI, bacterial lipopolysaccharide provides a dual signal on alveolar macrophages that induces cytokine production (TLR4-MyD88) and necrosis (P2X7R-CD14) that results in the early release of pro-IL-1α, which subsequently activates lung vessel endothelial cells (IL-1R-MyD88). This induces tight junction opening to allow neutrophils to infiltrate into the lungs, where they cause injury and inflammation. Dagvadorj's current research is focused on the regulation of interleukin-1 alpha in the setting of the inflammatory diseases.

Arditi Laboratory Cedars-Sinai Postdoctoral Researcher Gantsetseg Tumurkhuu, PhD

Gantsetseg Tumurkhuu, PhD

Postdoctoral Researcher Email: gantsetseg.tumurkhuu@cshs.org

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Gantsetseg Tumurkhuu, PhD, received her doctorate in immunology in 2008 from Aichi Medical University, Japan. Her research was focused on the function, signal transduction pathways and regulation of Toll-like receptors, especially lipopolysaccharide-mediated activation of innate immunity and septic shock. Her current studies involve investigating the molecular pathogenesis of mitochondrial DNA damage and the DNA repair protein OGG1 in atherosclerotic development and systemic lupus erythematosus.

Magali Noval Rivas, PhD

Magali Noval Rivas, PhD

Postdoctoral Fellow Email: magali.novalrivas@cshs.org

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Magali Noval Rivas, PhD, received her doctorate in immunological sciences at the Université Libre de Bruxelles, Belgium. After her postdoctoral studies at UCLA and Boston Children's Hospital/Harvard Medical School investigating the microbiome's influence and mechanisms of oral tolerance breakdown during food allergy, she joined the laboratory of Moshe Arditi, MD, where she is studying the role of the microbiome and mucosal immunology in the development of cardiovascular diseases.

Janet Markman, PhD

Janet Markman, PhD

Postdoctoral Fellow Email: janet.markman@cshs.org

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Janet Markman, PhD, received her doctorate from the Cedars-Sinai Biomedical Science and Translational Medicine Program. Markman is continuing her thesis work as a postdoctoral scientist in the Arditi Laboratory, where she studies the relationships among innate immunity, hormonal signaling and cancer.

Rebecca Porritt, PhD

Rebecca Porritt, PhD

Postdoctoral Fellow Email: rebecca.porritt@cshs.org

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Rebecca Porritt, PhD, received her doctorate at the Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Australia. During this time, her research focused on the innate immune response, specifically mechanisms regulating type I interferon signaling. To gain a greater understanding of the immune response as a whole, Porritt began a postdoctoral position at the Cedars-Sinai Inflammatory Bowel and Immunobiology Research Institute, researching the adaptive immune response. These studies focused on the regulation of CD4+ T cell responses at the intestinal mucosa, specifically in regard to inflammatory bowel disease and its influence on and interaction with the microbiome. Following this postdoctoral position, she began her second and current postdoctoral position under the guidance of Moshe Arditi, MD, and assistant professor Timothy R. Crother, PhD. These studies focus on innate and adaptive immune responses elicited against the respiratory pathogen C. pneumoniae. Specifically, Porritt is interested in the role of pDCs in the control of C. pneumoniae, as well as the regulation of CD4+ T cell responses during infection.

Nobuyuki Nosaka, MD, PhD

Nobuyuki Nosaka, MD, PhD

Postdoctoral Fellow Email: nobuyuki.nosaka@cshs.org

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Nobuyuki Nosaka, MD, PhD, received his medical degree from Nagoya University, Japan, and completed his training in pediatric critical care at National Center for Child Health and Development, Tokyo. He received his doctorate at Okayama University, Japan, where he focused on anti-inflammatory strategy against severe influenza pneumonia. Nosaka then joined the Arditi Laboratory, where he is studying the immunological mechanisms responsible for the development of ventilator-induced acute lung injury.

Masanori Abe, MD, PhD

Masanori Abe, MD, PhD

Postdoctoral Fellow Email: masanori.abe@cshs.org

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Masanori Abe, MD, PhD, received his doctorate in pediatrics in 2016 at the Nippon Medical School in Tokyo. Before coming to the U.S., Masanori was a pediatric cardiologist who worked clinically treating patients with Kawasaki disease. Abe joined the Arditi Laboratory in 2016. He studies the molecular mechanisms and cardiac function involved in the development of vasculitis in the mouse model of Kawasaki disease.

Kyle Madrid

Kyle Madrid

Graduate Student Email: kyle.madrid@cshs.org

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Kyle Madrid is a doctoral candidate in biomedical science and translational medicine at the Cedars-Sinai PhD program. For his undergraduate degree, Madrid transferred from Fresno City College to the University of California, Riverside, in 2013. He studied photocatalytic semiconductors in the nanomaterial synthesis lab of Yadong Yin, PhD. He received his bachelor of science in biochemistry in 2015. His current project in the Arditi Lab focuses on the influence of IL-1β on smooth muscle proliferation in Kawasaki disease.

Arditi Laboratory Cedars-Sinai Wenxuan Zhang Wenxuan Zhang

Wenxuan Zhang

Research Associate Email: wenxuan.zhang@cshs.org

Arditi Laboratory Cedars-Sinai Research Associate Ganghua Huang

Ganghua Huang

Research Associate Email: ganghua.huang@cshs.org

Changqing Zhang, PhD

Changqing Zhang, PhD

Research Associate III Email: changqing.zhang@cshs.org

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Changqing Zhang, PhD, earned her bachelor's degree in biological science from Peking University, China, and her doctorate in endocrinology and animal biosciences from Rutgers University. She investigated the effect of fetal alcohol exposure on neuroendocrine and immune function and cancer. Zhang joined Cedars-Sinai as a postdoctoral scientist working on immune reaction caused by cell transplantation in treating retina degeneration. She works in the Arditi Lab on transgenic mice colony maintenance and microdissection.

Michael Franklin

Michael Franklin

Research Associate II Email: michael.franklin@cshs.org

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Michael Franklin is working to complete his master's degree in biological sciences at California State University, Long Beach, where he investigates the mechanisms underlying sex differences in the structural development and functionality of the brain using rodent models. Franklin recently joined the Arditi Lab and plans to earn his doctorate in the near future.

Malcolm Lane

Malcolm Lane

Research Associate I Email: malcolm.lane@cshs.org

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Malcolm Lane began his career at Occidental College, where he investigated the effect of stem cells on neuronal repair in rodent models of epilepsy in the lab of Kerry Thompson, PhD. He graduated from Occidental College in 2015 with a bachelor's degree in biochemistry and a minor in mathematics. After graduation, Lane was recruited by an e-procurement software company as a professional services consultant for a yearlong project with IBM. He joined the Arditi Laboratory in 2016, where he works on transgenic mice colony maintenance and assists in a range of experiments in the lab.

Thacyana Teixeira de Carvalho

Thacyana Teixeira de Carvalho, MS

Visiting Graduate Student Email: thacyana.teixeiradecarvalho@cshs.org

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Thacyana Teixeira de Carvalho is a doctoral candidate in experimental pathology at State University of Londrina in Brazil. She has investigated the mechanisms involved in granulocyte colony-stimulating factor-induced mechanical hyperalgesia in mice and the role of flavonoids in this model. Carvalho joined Cedars-Sinai as a visiting graduate student in June 2017. Her current project in the Arditi Lab is in the mouse model of Kawasaki disease.