Cloning of angiotensin-converting enzyme

Bernstein KE, Martin BM, Edwards AS, Bernstein EA. Mouse angiotensin-converting enzyme is a protein composed of 2 homologous domains. Journal of Biological Chemistry. July 1989;264(20):11945-11951.


Cloning of AT1 receptor

Murphy TJ, Alexander RW, Griendling KK, Runge MS, Bernstein KE. Isolation of a cDNAencoding the vascular type-1 angiotensinII receptor. Nature. May 1991;351(6323):233-236.


AT1 receptor (7 transmembrane receptor) activates intracellular kinases

Marrero MB, Paxton WG, Duff JL, Berk BC, Bernstein KE. AngiotensinII stimulates tyrosine phosphorylation of phospholipase C-gamma1 in vascular smooth-muscle cells. Journal of Biological Chemistry. Apr 1994;269(14):10935-10939.


AT1 receptor activates Jak/STAT pathway

Marrero MB, Schieffer B, Paxton WG, Heerdt L, Berk BC, Delafontaine P, Bernstein KE. Direct stimulation of Jak/STAT pathway by the angiotensinII AT(1) receptor. Nature .May 1995; 375(6528):247-250.


Creation of ACE null mice

Esther CR Jr, Howard TE, Marino EM, Goddard JM, Capecchi MR, Bernstein KE. Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. Laboratory Investigation. May 1996;74(5):953-965.


Important role of tissue renin-angiotensin system

Esther CR Jr, Marino EM, Howard TE, Corvol P, Capecchi MR, Bernstein KE. The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice. Journal of Clinical Investigation. May 1997;99(10):2375-2385.


Angiotensin II and Erythropoiesis

Cole J, Ertoy D, Lin H, Sutliff RL, Ezan E, Guyene TT, Capecchi M, Corvol P, Bernstein KE.
Lack of angiotensin II–facilitated erythropoiesis causes anemia in angiotensin-converting enzyme–deficient mice
. Journal of Clinical Investigation. Dec 2000;106(11):1391-1398.


Testis ACE must be catalytically active for normal male fertility

Fuchs S, Frenzel K, Hubert C, Lyng R, Muller L, Michaud A, Xiao HD, Adams JW, Capecchi MR, Corvol P, Shur BD, Bernstein KE. Male fertility is dependent on dipeptidase activity of testis ACE. Nature Medicine. Nov 2005;11(11):1140-1142.


Role of ACE in infection

Okwan-Duodu D, Datta V, Shen XZ, Goodridge HS, Bernstein E, Fuchs S, Liu GY, Bernstein KE. Angiotensin-converting enzyme overexpression in mouse myelomonocytic cells augments resistance to Listeria and methicillin-resistant Staphylococcus aureus. Journal of Biological Chemistry. Dec 2010;285(50):39051-39060.


Role of ACE in MCH class I peptide presentation

Shen XZ, Billet S, Lin C, Okwan-Duodu D, Chen X, Bernstein KE. The carboxypeptidase angiotensin converting enzyme (ACE) shapes the MHC class I peptide repertoire. Nature Immunology. Oct 2011;12(11):1078-1085.

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