Publications

See a complete PubMed list of publications by Joshua Goldhaber, MD.

Selected Key Publications

Kapoor N, Tran A, Kang J, Zhang R, Philipson KD, Goldhaber JI. Regulation of calcium clock-mediated pacemaking by inositol-1,4,5-trisphosphate receptors in mouse sinoatrial nodal cells. J Physiol. 2015 Jun 15;593(12):2649-2663. http://onlinelibrary.wiley.com/doi/10.1113/JP270082/abstract.

Torrente AG, Zhang R, Zaini A, Giani JF, Kang J, Lamp ST, Philipson KD, Goldhaber JI. Burst pacemaker activity of the sinoatrial node in sodium-calcium exchanger knockout mice. Proc Natl Acad Sci USA. 2015;112(31):9769-9774. http://www.pnas.org/content/112/31/9769.

Bögeholz N, Pauls P, Bauer BK, Schulte JS, Dechering DG, Frommeyer G, Kirchhefer U, Goldhaber JI, Müller FU, Eckardt L, Pott C. Suppression of early and late afterdepolarizations by heterozygous knockout of the Na+/Ca2+ exchanger in a murine model. Circ Arrhythm Electrophysiol. 2015;8(5):1210-1218. http://circep.ahajournals.org/content/8/5/1210.

Shimizu H, Schredelseker J, Huang J, Lu K, Naghdi S, Lu F, Franklin S, Fiji HD, Wang K, Zhu H, Tian C, Lin B, Nakano H, Ehrlich A, Nakai J, Stieg AZ, Gimzewski JK, Nakano A, Goldhaber JI, et al. Mitochondrial Ca2+uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. Elife. 2015 Jan 15;4. http://elifesciences.org/content/4/e04801.

Torres NS, Sachse FB, Izu LT, Goldhaber JI, Spitzer KW, Bridge JH. A modified local control model for Ca2+ transients in cardiomyocytes: junctional flux is accompanied by release from adjacent non-junctional RyRs. J Mol Cell Cardiol. 2014 Mar;68:1-11. http://www.jmmc-online.com/article/S0022-2828(13)00368-4/abstract.

Myerburg RJ, Halperin H, Egan DA, Boineau R, Chugh SS, Gillis AM, Goldhaber JI, Lathrop DA, Liu P, Niemann JT, et al. Pulseless electrical activity: definition, causes, mechanisms, management, and research priorities for the next decade: report from a National Heart, Lung, and Blood Institute workshop. Circulation. 2013 Dec 3;128(23):2532-2541. http://circ.ahajournals.org/content/128/23/2532.

Groenke S, Larson ED, Alber S, Zhang R, Lamp ST, Ren X, Nakano H, Jordan MC, Karagueuzian HS, Roos KP, Nakano A, Proenza C, Philipson KD, Goldhaber JI. Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity. PLOS One. 2013 Nov 21;8(11):e81633. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081633.

Okada H, Lai NC, Kawaraguchi Y, Liao P, Copps J, Sugano Y, Okada-Maeda S, Banerjee I, Schilling JM, Gingras AR, Asfaw EK, Suarez J, Kang SM, Perkins GA, Au CG, Israeli-Rosenberg S, Manso AM, Liu Z, Milner DJ, Kaufman SJ, Patel HH, Roth DM, Hammond HK, Taylor SS, Dillmann WH, Goldhaber JI, Ross RS. Integrins protect cardiomyocytes from ischemia/reperfusion injury. J Clin Invest. 2013 Oct;123(10):4294-308. http://www.jci.org/articles/view/64216.

Ottolia M, Torres N, Bridge JH, Philipson KD, Goldhaber JI. Na/Ca exchange and contraction of the heart. J Mol Cell Cardiol. 2013 Aug;61:28-33. http://www.jmmc-online.com/article/S0022-2828(13)00200-9/abstract.

Pott C, Muszynski A, Ruhe M, Bögeholz N, Schulte JS, Milberg P, Mönnig G, Fabritz L, Goldhaber JI, Breithardt G, et al. Proarrhythmia in a non-failing murine model of cardiac-specific Na+/Ca 2+ exchanger overexpression: whole heart and cellular mechanisms. Basic Res Cardiol. 2012 Mar;107(2):247. http://link.springer.com/article/10.1007%2Fs00395-012-0247-7.

Nsair A, Schenke-Layland K, Van Handel B, Evseenko D, Kahn M, Zhao P, Mendelis J, Heydarkhan S, Awaji O, Vottler M, Geist S, Chyu J, Gago-Lopez N, Crooks GM, Plath K, Goldhaber JI, et al. Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells. PLOS One. 2012;7:e45603. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045603.

Angelis E, Zhao P, Zhang R, Goldhaber JI, Maclellan WR. The role of E2F-1 and downstream target genes in mediating ischemia/reperfusion injury in vivo. J Mol Cell Cardiol. 2011 Dec;51(6):919-926. http://www.jmmc-online.com/article/S0022-2828(11)00411-1/abstract.

Schenke-Layland K, Nsair A, Van Handel B, Angelis E, Gluck JM, Votteler M, Goldhaber JI, Mikkola HK, Kahn M, Maclellan WR. Recapitulation of the embryonic cardiovascular progenitor cell niche. Biomaterials. 2011 Apr;32(11):2748-2756. http://www.sciencedirect.com/science/article/pii/S0142961210016194.

Torres N, Larbig R, Rock A, Goldhaber JI, Bridge JHB. Na+ currents are required for efficient excitation-contraction coupling in rabbit ventricular myocytes: a possible contribution of neuronal Na+ channels. J Physiol (London). 2010 Nov 1;588:4249-4260. http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2010.194688/abstract.

Larbig R, Torres N, Bridge JHB, Goldhaber JI, Philipson KD. Activation of reverse Na+-Ca2+exchange by the Na+ current augments the cardiac Ca2+transient: evidence from NCX knockout mice. J Physiol (London). 2010 Sep 1;588(PT-17):3267-3276. http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2010.187708/abstract.

Jumabay M, Zhang R, Yao Y, Goldhaber JI, Boström KI. Spontaneously beating cardiomyocytes derived from white mature adipocytes. Cardiovasc Res. 2010;85(1):17-27. http://cardiovascres.oxfordjournals.org/content/85/1/17.

Neco P, Rose BA, Huynh N, Zhang R, Bridge JHB, Philipson KD, Goldhaber JI. Sodium-calcium exchange is essential for effective triggering of calcium release in mouse heart. Biophys J. 2010;99:755-764. http://www.cell.com/biophysj/abstract/S0006-3495(10)00621-1.