Publications

Selected Key Publications

Mentzer RM Jr, Wider J, Perry CN, Gottlieb RA. Reduction of infarct size by the therapeutic protein TAT-Ndi1 in vivo. J Cardiovasc Pharmacol Ther. 2013 Dec 23. [Epub ahead of print] PMID: 24367006.

Hernandez G, Thornton C, Stotland A, Lui D, Sin J, Ramil J, Magee N, Andres A, Quarato G, Carreira RS, Sayen MR, Wolkowicz R, Gottlieb RA. MitoTimer: A novel tool for monitoring mitochondrial turnover. Autophagy. 2013 Nov 1;9(11):1852–1861.
Epub 2013 Oct 11. PMID: 24128932.

Andres AM, Hernandez G, Lee P, Huang C, Ratliff EP, Sin J, Thornton CA, Damasco MV, Gottlieb RA. Mitophagy is required for acute cardioprotection by simvastatin. Antioxid Redox Signal. 2013 Sep 20. [Epub ahead of print] PMID: 23901824.

Jahania SM, Sengstock D, Vaitkevicius P, Andres A, Ito BR, Gottlieb RA, Mentzer RM Jr. Activation of the homeostatic intracellular repair response during cardiac surgery. J Am Coll Surg. 2013 Apr;216(4):719–726; discussion 726–729. Epub 2013 Feb 13. PMID: 23415552; PMCID: PMC3724756.

Gottlieb RA, Mentzer RM Jr. Autophagy: An affair of the heart. Heart Fail Rev. 2013 Sep;18(5):575–584. PMID: 23188163; PMCID: PMC3782636.

Tabor-Godwin JM, Tsueng G, Sayen MR, Gottlieb RA, Feuer R. The role of autophagy during coxsackievirus infection of neural progenitor and stem cells. Autophagy. 2012 Jun;8(6):938–953. Epub 2012 Jun 1. PMID: 22751470; PMCID: PMC3427259.

Perry CN, Huang C, Liu W, Magee N, Carreira RS, Gottlieb RA. Xenotransplantation of mitochondrial electron transfer enzyme, Ndi1, in myocardial reperfusion injury. PLoS One. 2011 Feb 14;6(2):e16288. PMID: 21339825; PMCID: PMC3038860.

Sala-Mercado JA, Wider J, Undyala VV, Jahania S, Yoo W, Mentzer RM Jr, Gottlieb RA, Przyklenk K. Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injury. Circulation. 2010 Sep 14;122(11 Suppl):S179–184. PMID: 20837911; PMCID: PMC3355994.

Huang C, Yitzhaki S, Perry CN, Liu W, Giricz Z, Mentzer RM Jr, Gottlieb RA. Autophagy induced by ischemic preconditioning is essential for cardioprotection. J Cardiovasc Transl Res. 2010 Aug;3(4):365–373. Epub 2010 May 11. PMID: 20559777; PMCID: PMC2899015.

Huang C, Zhang X, Ramil JM, Rikka S, Kim L, Lee Y, Gude NA, Thistlethwaite PA, Sussman MA, Gottlieb RA, Gustafsson AB. Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice. Circulation. 2010 Feb 9;121(5):675–683. pub 2010 Jan 25. PMID: 20100968; PMCID: PMC2834271.

 

See a current list of publications from the Gottlieb Laboratory.
The publications cover several topics: autophagy/mitophagy (Gottlieb Lab), cardioprotection (collaboration with Robert Mentzer Jr., MD of Wayne State University); and investigations into the microbial basis of heart disease. The microbial work involves collaborations with Ralph Feuer (coxsackievirus), Scott Kelley (oral microbiome), Kelly Doran (gram-positive bacteria) and Patricia Romano (Trypanosoma cruzi).

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