Reducing Spinal Cord Injury After Endovascular and Open Aortic Operations
Spinal cord injury (SCI) is the most feared complication of patients undergoing major aortic surgery, and reducing spinal cord injury after endovascular and open aortic operations is one focus of our research. In the literature, the incidence is reported to be up to 14%, and once an ischemic SCI has occurred, whether early or delayed, the possibility of a recovery remains low. Therefore effective strategies to prevent spinal cord damage are of utmost importance. In a standardized model, the effects of neuroprotective agents will be evaluated under neurophysiologic and hemodynamic monitoring.
Aortic and Aortic Valve Research
Furthermore, the Khoynezhad Laboratory is evaluating pathophysiological pathways of aortic aneurysm and dissection, and is developing novel standardized in vitro and in vivo models that can be translated into clinical practice in aortic disease. In vitro models are sensor equipped, and will display common diseases, such as aneurysms and dissections of the aorta. They will serve as study objects to explore the catheter-tissue interaction and for training purposes.
Modeling of Thoracic Aortic Pathologies
Development of Endovascular Devices and Intracardiac Micro Surgery
Last but not least, novel technologies to treat ascending aortic and aortic root disease are investigated, with the aim of improving indications for endovascular therapeutics. The development of in vitro as well as in vivo testing of new endovascular or intracardiac treatment options for aortic and aortic valve disease will be performed combining medical knowledge with advanced bioengineering.